Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article - Biomedical Research (2017) Volume 28, Issue 16

Closed loop blood glucose control in diabetics

Diabetes is a chronic metabolic disorder affecting millions of people worldwide. Especially, type-1 diabetics have required strict glycemic control. In this paper, close loop control system is designed to normalize the high blood glucose level for diabetes patients. Glucose-insulin dynamics in blood plasma are represented by Bergman minimal mathematical model which is used as base model. The dynamical variations between different and same individual poses a major challenge in designing of controller for biological systems. The contribution of this research work lies in designing a backstepping based nonlinear controller which perfectly deals with nonlinearities present in the system. In order to visualize the robust behavior, meal and exercise are added as a disturbance factor and controller effectively track the set point value of 70 mg/dL from an initial state of hyperglycemia. The control criteria imposed on the proposed controller are hyperglycemia and hypoglycemia.

Author(s): Faiz-Ul-Hassan, Muhammad Adil, Ali Khaqan, Sana Shuja, Moazzam Islam Tiwana, Qadeer-ul-Hassan, Shahzad Malik, Raja Ali Riaz

Abstract Full Text PDF