Biomedical Research

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Clinical significance of plasma levels of N-terminal brain natriuretic peptide and copeptin in patients with acute cerebral haemorrhage

Objective: To investigate the clinical significance of plasma levels of N-terminal Brain Natriuretic Peptide (NT-proBNP) and copeptin in patients with acute cerebral haemorrhage.

Methods: 126 patients with acute cerebral haemorrhage from June 2015 to August 2016 in our hospital were chosen as the observation group. In the same period, 60 health participants were included into the control group. The plasma levels of NT-proBNP and copeptin of the two groups were tested and compared. According to the different amount of bleeding, the observation group were divided into massive cerebral haemorrhage group (29 cases), medium cerebral haemorrhage group (57 cases) and a small cerebral haemorrhage group (40 cases). According to the prognosis of the patients, the observation group were divided into death group (24 cases) and survival group (102 cases). The plasma levels of NTproBNP and copeptin in patients with different bleeding volume and prognosis were analysed.

Results: Plasma levels of NT-proBNP and copeptin of the observation group were significantly higher than that of the control group, with significant difference (t=34.21 P<0.05, t=34.85 P<0.05 respectively). Plasma levels of NT-proBNP and copeptin of the massive cerebral haemorrhage group (29 cases), the medium cerebral haemorrhage group and the small cerebral haemorrhage group were synchronously decreased, and there were significant differences among three groups (small group vs. mild group, q=6.36, P<0.05, small group vs. massive group, q=41.67, P<0.05, mild group vs. massive group, q=38.83, P<0.05). Compared with the death group, plasma levels of NT-proBNP and copeptin of the survival group were significantly reduced, the difference was statistically significant (t=26.86, P<0.05, t=6.98, P<0.05 respectively). There were a significant positive correlation between the plasma levels of NTproBNP, copeptin and the amount of cerebral haemorrhage (r=0.54, P<0.05, r=0.48, P<0.05 respectively), GCS score (r=0.43, P<0.05, r=0.37, P<0.05 respectively).

Conclusion: Early combined detection of plasma levels of NT-proBNP and copeptin in patients with acute cerebral haemorrhage can reflect the severity of cerebral haemorrhage; assess the prognosis of patients, which have a certain clinical referential value.

Author(s): Niu Ruina, Teng Fangjun