Biomedical Research

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Clinical application of the combined determination of neutrophil elastase, fetal fibronectin, and cervical length in predicting preterm birth of twin pregnancies

In total, 115 pregnant women underwent detection of Neutrophil Elastase (NE) and Fetal Fibronectin (fFN), and measurement of Cervical Length (CL) 20-34 weeks into pregnancy. The clinical value of these values in predicting preterm birth was analysed retrospectively. In the 29 women who gave birth before 34 weeks, the CL value (21.3 ± 9.8 mm) and the fFN and NE rates (65.5% and 75.9%, respectively) were significantly different compared with women undergoing childbirth after 34 weeks (P<0.05). The combined detection rate of CL and fFN was 78.6%, CL and NE was 84.4%, and fFN and NE was 88.9%. Moreover, the combined detection rate of CL, NE and fFN was 100%. The predictive value of premature labor in twin pregnancy using multiple markers was more successful than that of a single marker; therefore, these multiple markers could be used to evaluate clinical intervention.

Author(s): Xudong Dong, Iwashita M, Fang Ai, Jiang Jiang, Huanling Liu, Yunping Wu