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Change in the red blood cell immunity function and T-lymphocyte and its subpopulations before and after acute incremental load exercise

Objective: This paper discusses the changes in the Red Blood Cells (RBC) immunity function and Tlymphocyte and its sub-populations before and after acute incremental load exercise.

Methods: A total of 112 patients in our hospital from January 2015 to May 2016 were selected as research objects. Blood samples at four stages (before the exercise (T1), 1 min (T2), 0.5 h (T3) and 24 h (T4) after the acute incremental load exercise) were collected from antecubital veins. Changes in RBCC3bRR, RBC-ICR, CD3+, CD4+, CD8+ and CD4+/CD8+ before and after the exercise were compared.

Results: The RBC-C3bRR values at T2 and T3 were 6.22 ± 0.94% and 6.95 ± 0.79%, respectively, which were significantly lower than the value before the exercise (8.32 ± 1.03%) (P<0.05). The RBC-ICR values at T2 and T3 were 16.97 ± 1.37% and 16.53 ± 1.44%, respectively, which were significantly higher than the value before the exercise (15.32 ± 1.65%) (P<0.05). However, these two indexes recovered to the normal state at T4 but were slightly lower than the value before the exercise. No significant differences were observed between the two groups (P>0.05). CD3+, CD4+, CD8+ and CD4+/CD8+ at T3 decreased continuously and recovered to the normal conditions at T4. T-lymphocyte and its subpopulations changed slightly before and after the acute incremental load exercise. The difference between groups had no statistical significance (P>0.05).

Conclusions: After the acute incremental load exercise, RBC-C3bRR in human blood decreased significantly, whereas RBC-ICR increased dramatically, indicating potential risks of secondary erythrocyte immunodeficiency. Erythrocyte immunosuppression persisted until 24 h after the exercise. The T-lymphocyte level and CD4+/CD8+ decreased continuously after the exercise and recovered to normal levels 24 h later. No significant fluctuations were observed in T-lymphocyte and its subpopulations.

Author(s): Qian Li, Bo Li, Hong-Long Xu, Yun-Fei Li