Mycobacterium avium complex organisms mainly affect immunocompromised patients, presenting as lymphadenitis in children. The host's defense against intracellular infections, especially non-tuberculosis mycobacterium, depends mainly on the function and activity of Interferon Gamma (IFN-G) and Interleukin 12 (IL-12). Here we present a case of a sevenmonth- old boy presented with multiple neck and axillary swellings. The patient was treated medically and then came back with a relapse. Eventually, he was diagnosed with IL-12 deficiency.