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Association of genetic polymorphisms in toll-like receptor 2 (TLR2) and susceptibility to hepatocellular carcinoma

Purpose: Toll-like receptors (TLR) act as a vital innate immunity receptors involved in immune response. More and more evidence implies that mutations of TLR2 gene are correlated with cancers. This retrospective study aimed to identify variants in TLR2 affecting HCC (Hepatocellular Carcinoma) susceptibility.

Methods: Four tgSNPs (tag SNPs) were chose from HapMap data and genotyped in 274 patients with HCC and 277 healthy controls.

Results: Rs3804099 genotype CT (P=0.0001, OR=2.00) and allele T (P=0.019, OR=1.37) showed significant difference between HCC and HC (Healthy Control). People who carried rs7656411 genotype TT (P=0.002, OR=2.18) and allele T (P=0.002, OR=1.46) had a significant association with increased HCC risk. The results were consistent with previous results in dominant or recessive model (P=0.001, OR=1.81; P=0.014, OR=1.58; P=0.009, OR=1.78).

Conclusions: Rs3804099 polymorphism C/T and rs7656411 polymorphism G/T in TLR2 were significantly correlated with HCC susceptibility.

Author(s): Zhongchao Huo, Xueling Wang, Xiaolei Shu, Chunbo Fan, Xian Zhou