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Association between IL-8 genetic polymorphisms and the risk of ovarian cancer in a Chinese population

Objective: To perform a 1:1 matched case-control study to evaluate the role of IL-8 rs4073, rs1126647 and rs2227306 polymorphisms in the development of ovarian cancer in a population of China.

Methods: A total of 280 patients with ovarian cancer and 280 healthy controls were recruited. Genotyping of IL-8 rs4073, rs1126647 and rs2227306 were run in a 384-well plate format on the sequenom MassARRAY platform.

Results: Patients with ovarian cancer were more likely to have higher BMI (OR=1.12, 95% CI=1.06-1.17), a long term use of hormone replacement therapy (OR=3.58, 95% CI=1.28-10.01) and a habit of alcohol drinking (OR=1.47, 95% CI=1.01-2.14). Moreover, those carrying the AT (OR=1.50, 95% CI=1.05-2.16) and TT (OR=2.26, 95% CI=1.18-4.35) genotypes were associated with a higher risk of ovarian cancer when compared with those with the AA genotype. The AT+TT genotype was correlated with higher risk of ovarian cancer in comparison to the AA genotype (OR=1.58, 95% CI=1.12-2.24). A linkage disequilibrium was found between rs4073 and rs1126647 (D'=0.572, r2=0.12). A total of four common haplotypes (frequency>0.03) were selected into analysis, and the A-C-T haplotype showed a reduced risk of ovarian cancer, with the OR (95% CI) of 0.74 (0.56-0.99).

Conclusions: Our results support direct association of IL-8 rs4073 polymorphism and A-C-T haplotype with the risk of ovarian cancer, suggesting that the IL-8 may be a new biomarker for the susceptibility to ovarian cancer.

Author(s): Yuchong Hu, Jingkun Lu, Aiming Wang