We aimed to investigate the association between IL-4 genetic polymorphisms (IL-4 rs2243250, rs2227284, rs2243267, rs2243270) and risk of CAD in a Han Chinese individual. A total of 366 patients with coronary artery disease patients and 366 controls were collected from July 2014 to July 2016. SNP genotyping of IL-4 rs2243250, rs2227284, rs2243267 and rs2243270 was done in a 384-well plate format on the sequenom Mass ARRAY platform. Conditional logistic regression analysis was performed to analyze the relationship between the four SNPs and risk of CAD. We found that those with BMI ≥ 24 (adjusted OR=2.71, 95% CI=1.70-4.30), T2DM (adjusted OR=2.59, 95% CI=1.61-4.17) or hypertension (adjusted OR=2.10, 95% CI=1.47-3.00) were associated with an increased risk of CAD compared with the reference group. The TT (adjusted OR=2.86, 95% CI=1.75-4.68) and CT+TT (adjusted OR=1.39, 95% CI=1.02-1.90) genotypes of rs2243250 were correlated with an elevated risk of CAD when compared with the CC genotype. The GG genotype of rs2243270 was associated with a higher risk of CAD in comparison to the AA genotype (adjusted OR=1.97, 95% CI=1.22-3.18). Our study suggests that IL-4 may be a useful biomarker for prediction of the susceptibility of this study.