Biomedical Research

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Analysis on the expression level of serum MMP-7 in patients with abdominal aortic aneurysm accompanied by hypertension and clinical efficacy of endovascular graft exclusion

Objective: To investigate the expression level of serum MMP-7 in patients with abdominal aortic aneurysm accompanied by hypertension and clinical efficacy of endovascular graft exclusion.

Methods: A retrospective analysis of 72 patients with abdominal aortic aneurysm accompanied by hypertension in our hospital was conducted. They were divided into observation group and control group with 34 and 38 cases respectively in the each group. The control group was given abdominal aortic aneurysm incision with artificial blood vessel replacement, and the observation group was given endovascular graft exclusion. During the same period, there were 72 healthy people with age and sex matched who went to our physical examination center, and 72 patients with hypertension treated in our hypertension department. ELISA method was applied to detect the serum MMP-7 expression levels in aneurysm patients accompanied by hypertensive, hypertensive patients and healthy people, who were enrolled in the study. After endovascular graft exclusion, patients’ aortic aneurysm tissue and adjacent to normal artery of aneurysm were collected to conduct immumohistochemical staining to detect the expression levels of MMP-7 in aneurysmal tissue.

Results: ELISA assay showed that MMP-7 level of patients with aneurysm was significantly higher than that of simple hypertension patients, and the difference was statistically significant (P<0.05). The surgeries were successful in aneurysm patients accompanied by hypertension in the study. The operative time, blood loss and blood transfusion of the observation group were significantly less than that of the control group, and the differences were statistically significant (P<0.05). The Patients were followed up after surgery for one month, the overall incidence of pulmonary infection, incision infection, lower limb thrombosis, lower limb weakness and other complications in the observation group was significantly lower than that of the control group (P<0.05). Quality of life scores of the observation group after one month and three months were significantly higher than that of the control group, and the differences were significant (P<0.05). Results of immumohistochemical staining showed that MMP-7 expression level in the aneurysm tissue was significantly higher than that in adjacent to normal tissue of aneurysm. Serum MMP-7 expression levels of the two groups were significantly decreased than that before treatment, and the difference was statistically significant (P<0.05).

Conclusion: Through detecting MMP-7 expression levels in patients with hypertension has a role in early warning for the occurrence of abdominal aortic aneurysm. The application of endovascular graft exclusion for the treatment of abdominal aortic aneurysm accompanied by hypertension has minimal invasion, safety and other advantages with stable vital signs and improved life quality of the prognosis.

Author(s): Dezhi Liu, Boyu Liu, Xiaokai Zhang, Qingjie Ma