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July 05-06, 2019 | Paris, France

Pharmaceutics and Advanced Drug Delivery Systems

2

nd

International Conference and Exhibition on

Asian Journal of Biomedical and Pharmaceutical Sciences | ISSN:2249-622X | Volume 9

Water inclusion effect on starch 1500 as an excipient used in the production of the oral

solid dosage form

Saeid Rajabnezhad, Taravat Ghafourian, Ali Rajabi-Siahboomi, Shahrzad Missaghi, Majid Naderi

and

Ali

Nokhodchi

University of Sussex, UK

S

tarch 1500 is a well-known diluent, binder, disintegrant

and dissolution enhancer, which is widely used in the

formulation of the oral solid dosage forms. To validate the

proposed hypothesis that whether Starch 1500 preserves

the chemical hydrolysis of the moisture sensitive drugs,

the understanding the sorption-desorption behaviour of

this excipient is the first challenge. Water molecules when

interacting with most of the pharmaceutical excipients

and APIs localise within the crystalline part of the physical

structure. Specifically, for starch-based excipients, crystal

regions of the structure host the water molecules within the

double-stranded helices of the crystallite. DSC TGA, FTIR-ATR

and NIR techniques were adopted to determine the freezable

and nonfreezable bound water with starch 1500, both

qualitatively and quantitively. Among different mathematical

models, Young and Nelson model have not well practised

compared to the other available models, such as BET, GAB,

Oswin and Smith models. It was found out that Young and

Nelson model along with the GAB theory well carver the

sorption isotherms. The variable parameters obtained from

these two equations were compared and the monolayer

valuewas estimated. The amount ofmonolayer coveragewith

the assumption of the strength of the binding of the water

molecules on the first accumulated layer was correlated with

the total water content of the Starch 1500. Analysis of the

strength of the hydrogen bonds between Starch 1500 and the

water molecules, mobility and the availability of the reactive

water molecules to take part in chemical hydrolytic reactions

could be explained.

Speaker Biography

Saeid Rajabnezhad is a registered pharmacist since 2009. Beside working

as a community and hospital pharmacist, his main professional activities

are formulation development, quality control and production of oral solid

dosage forms as an industrial pharmacist. He has served various roles such

as R&D, QC and deputy of production manager in several pharmaceutical

companies. He was then joined the research group of Prof Ali Nokhodchi

at the University of Sussex, UK as a PhD researcher. His research is funded

through the University of Sussex and Colorcon Ltd. Saeid is in his final year

of PhD programme. He has published several articles in peer-reviewed

pharmacy journals in pharmaceutical technology, drug delivery and

nanoparticulate matters, powder engineering, characterisation as well as

analytical method development.

e:

s.rajabnezhad@sussex.ac.uk

Saeid Rajabnezhad et al.

, Asian J Biomed Pharmaceut Sci, | ISSN: 2249-622X

Volume 9