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July 05-06, 2019 | Paris, France
Pharmaceutics and Advanced Drug Delivery Systems
2
nd
International Conference and Exhibition on
Asian Journal of Biomedical and Pharmaceutical Sciences | ISSN:2249-622X | Volume 9
A comparative study of co-processed natural disintegrants with the commonly used
disintegrants
Jaydeep Patel
and
Jiten Shanishchara
B K Mody Government Pharmacy College, India
T
he present research work deals with preparing spray
dried co-processed natural disintegrant which has an
excellent disintegration efficiency. Based on the preprimary
trial results, chitin and corn starch were selected as an
excipients to be co-processed and range of the processing
parameters for spray dryingwere optimized. 3
2
Full factorial
design was applied, where ratio of chitin:corn starch (X1) &
In-let air temperature (X2) were selected as independent
factors. Here wetting time, water absorption ratio and In-
vitro disintegration were selected as dependent response
variables. Comparative evaluation of the optimized co-
processed natural disintegrant, Sodium starch glycolate
(SSG) and Cross carmelose sodium (CCS) were carried out
by formulating tablets with the propranolol hydrochloride
and Ibuprofen. Lowest In-vitro disintegration time,
wetting time and water absorption ratio for the Lactose
monohydrate and D- Mannitol tablets were 29 sec, 30 sec,
75.12% and 31 sec, 28 sec, 80.07%. Almost similar results
were obtained in the tablets with Lactose monohydrate
and D-Mannitol as a diluent. Optimized batch having
Chitin:corn starch in a 50:50 ratio when spray dried at
In-let air temperature of 180 °C, provides co-processed
natural disintegrant having excellent disintegration
efficiency. All the evaluation parameters of the optimized
batch met the acceptance criteria. In-vitro disintegration
time of formulated propranolol hydrochloride tablets
with optimized co-processed natural disintegrant, SSG
and CCS were 31 sec, 58 sec & 52 sec respectively. In-vitro
disintegration time of formulated Ibuprofen tablets with
optimized co-processed natural disintegrant, SSG and CCS
were 25 sec, 33 sec &30 sec respectively. Stability data of all
tablets shows no significant change during stability period
& they were in an acceptable range. It was found to have
versatile disintegration efficiency without being affected
by the type of diluent used and without being affected by
the class/dose of active pharmaceutical ingredient to be
used with. Order of the disintegration efficiency was Co-
processed natural disintegrant > CCS > SSG.
Speaker Biography
Jaydeep Patel has completed his PhD at the age of 29 from
Hemchandracharya North Gujarat University, India. He is working as
Class-II Senior Lecturer at B K Mody Government Pharmacy College,
India. affiliated with Gujarat Technological University, India. He has
more than 10 years of teaching and research experience. His area of
research is preformulation and novel drug delivery system. He has
published and presentated various research papers in many National
and International conferences.
e:
jaydeepbkmgpc@gmail
Jaydeep Patel et al.
, Asian J Biomed Pharmaceut Sci, | ISSN: 2249-622X
Volume 9