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Page 25

N o v e m b e r 2 1 - 2 2 , 2 0 1 8 | M a d r i d , S p a i n

OF EXCELLENCE

IN INTERNATIONAL

MEETINGS

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YEARS

Nephrology 2018

Journal of Clinical Nephrology and Therapeutics

|

Volume 2

NEPHROLOGY AND UROLOGY

International Conference on

Roman Aizman et al., J Clin Nephrol Ther 2018, Volume 2

EFFECT OF CALCIUM AND MAGNESIUM

HIGH CONTENT IN HARDNESS DRINKING

WATER ON KIDNEY FUNCTIONS

Roman Aizman, Svetlana Nedovesova

and

Eugene Trofimovich

Novosibirsk State Pedagogical University, Russia

T

he effects of prolonged consumption of hardness drinking water with in-

creased content of Mg

2+

and Ca

2+

on renal functions in rats were studied.

The experiments were performed on Wistar male rats of 3 groups: control (C)

(Ca

2+

-10 mg/L and Mg

2+

-5 mg/L), and experimental – E1 (Ca

2+

-120mg/L ) and

E2 (Mg

2+

-60mg/L). At the 1-st, 2-d, 4-th and 6-th months of water intake in

rats the urine and blood samples were collected before (background) and af-

ter a 5% water load. The concentrations of Na

+

, K

+

, Ca

2+

, Mg

2+

, urea, osmolality

and hormones (corticosterone, T3 and T4) were determined. It was shown

that both experimental groups an activation of osmoregulatory renal function

compared with the control have manifested, that was to reduce urine output

by increasing of fluid reabsorption, the osmolality of the urine, the excretion

of Ca

2+

and reducing potassium and magnesium excretion. The output of Na

+

,

urea practically did not differ between groups. Drinking water in group E2

caused more significant changes in renal function than water in group E1. Af-

ter the water loading differences in renal response between the groups were

not expressed, especially to the 6-th month, indicating a decrease in the level

of stress of the osmotic and ion - regulating mechanisms after hydration. The

concentration of the described ions in plasma did not differ between groups,

and the content of the main stress hormones (corticosterone, thyroxine, tri-

yiodothyronine) responsible for adaptive adjustment of the organism by the

end of the observation was significantly lower than in the group C, which is

likely to indicate a manifestation of a stress reaction to hardness drinking

water with its subsequent depletion. Thus, long-term intake of drinking water

with high content of Mg

2+

and Ca

2+

causes adaptive adjustment of hormonal

and renal responses, the value of which depends on the concentration of ions

in the water and the consumption time duration.

Roman Aizman has got his Doctor degree from Moscow

Research Institute of Developmental Physiology in 1985.

He is the head of the dept. of Human Anatomy, Physi-

ology and Life Safety, director of the Scientific Research

Institute of Health and Safety, professor of Novosibirsk

State Pedagogical University, Russia. He has over 700

publications that have been cited over 3900 times, and

his publication H-index is 26.

[email protected]

BIOGRAPHY