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N o v e m b e r 2 1 - 2 2 , 2 0 1 8 | M a d r i d , S p a i n
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
Nephrology 2018 Journal of Clinical Nephrology and Therapeutics| Volume 2
NEPHROLOGY AND UROLOGY
International Conference on
Aikaterini Nouri, J Clin Nephrol Ther 2018, Volume 2
THE RELATION BETWEEN DIABETES AND
DEMENTIA IN PATIENTS UNDERGOING
DIALYSIS
Aikaterini Nouri
Alexander Technological Educational Institute of Thessaloniki, Greece
Introduction and Aims: End-stage renal disease (ESRD) patients, undergoing
maintenance hemodialysis often suffer from depression and dementia. How-
ever, the relation between diabetes and depression and/or dementia to those
patients has not yet been efficiently examined. Purpose of the study was to
investigate the effect of diabetes on depression and dementia in a population
of chronic ESRD patients undergoing maintenance dialysis.
Methods: 53 patients (mean age 69.57±13.02 years, 15 male / 38 female)
undergoing maintenance thrice-weekly dialysis for 28.34±56.36 months were
included in the study. 27 of them had established diabetes mellitus. During a
dialysis session, all patients were interviewed using the standardized ques-
tionnaires “Mini Mental State Examination” (MMSE) and “Hospital Anxiety
and Depression Scale” (HADS) to determine the level of depression and de-
mentia. Fasting blood samples were taken in order to determine hemoglobin
levels, dialysis adequacy (determined by kt/V) and serum levels of sodium,
potassium, calcium and phosphorus. Inflammation status was assessed by
serum levels of C-reactive protein (CRP).
Results: The level of depression and dementia for the total of our population
was defined as moderate (13.91±10.56 and 15.00±5.49 degrees respective-
ly). Diabetics showed significantly higher depression level than non-diabetics
(17.63±10.63 vs 10.04±9.15 respectively, p<0.05). Although dementia level
was assessed as moderate for the total of our population, non-diabetics pre-
sented significantly lower dementia level than diabetic patients (13.19±5.19
vs 16.88±5.23 respectively, p<0.05). In the non-diabetic group there was a
significant difference of depression level among sexes (men 8.79±7.70 vs
women 13.43±12.35, p<0.05). However, there was no difference of dementia
levels among men and women. CRP circulating levels were correlated with
dementia (r=0.487, p<0.05), while no association was found between CRP
and depression. In diabetics, no relation between dementia/depression and
gender or CRP levels was established.
Conclusions: ESRD dialysis patients suffer from moderate depression and
dementia. In those patients, depression is closely related with the presence
of diabetes. In non-diabetic dialysis patients we found a strong association
of female gender and depression status and high inflammatory status with
dementia.
Aikaterini Nouri has completed her MSc at the age of 25
years fromAlexander Technological Educational Institute
of Thessaloniki and post nursing studies also from Alex-
ander Technological Educational Institute of Thessaloni-
ki. She is editor of essay with title “The relation between
diabetes and dementia for patients undergoing dialysis”.
At the 9th European nursing conference which held in
Heraklion, Crete, Greece, she has presented a diabetic
related essay.
BIOGRAPHY