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Page 15

N o v e m b e r 2 1 - 2 2 , 2 0 1 8 | M a d r i d , S p a i n

OF EXCELLENCE

IN INTERNATIONAL

MEETINGS

alliedacademies.com

YEARS

Nephrology 2018

Journal of Clinical Nephrology and Therapeutics

|

Volume 2

NEPHROLOGY AND UROLOGY

International Conference on

Aikaterini Nouri, J Clin Nephrol Ther 2018, Volume 2

THE RELATION BETWEEN DIABETES AND

DEMENTIA IN PATIENTS UNDERGOING

DIALYSIS

Aikaterini Nouri

Alexander Technological Educational Institute of Thessaloniki, Greece

Introduction and Aims:

End-stage renal disease (ESRD) patients, undergoing

maintenance hemodialysis often suffer from depression and dementia. How-

ever, the relation between diabetes and depression and/or dementia to those

patients has not yet been efficiently examined. Purpose of the study was to

investigate the effect of diabetes on depression and dementia in a population

of chronic ESRD patients undergoing maintenance dialysis.

Methods:

53 patients (mean age 69.57±13.02 years, 15 male / 38 female)

undergoing maintenance thrice-weekly dialysis for 28.34±56.36 months were

included in the study. 27 of them had established diabetes mellitus. During a

dialysis session, all patients were interviewed using the standardized ques-

tionnaires “Mini Mental State Examination” (MMSE) and “Hospital Anxiety

and Depression Scale” (HADS) to determine the level of depression and de-

mentia. Fasting blood samples were taken in order to determine hemoglobin

levels, dialysis adequacy (determined by kt/V) and serum levels of sodium,

potassium, calcium and phosphorus. Inflammation status was assessed by

serum levels of C-reactive protein (CRP).

Results:

The level of depression and dementia for the total of our population

was defined as moderate (13.91±10.56 and 15.00±5.49 degrees respective-

ly). Diabetics showed significantly higher depression level than non-diabetics

(17.63±10.63 vs 10.04±9.15 respectively, p<0.05). Although dementia level

was assessed as moderate for the total of our population, non-diabetics pre-

sented significantly lower dementia level than diabetic patients (13.19±5.19

vs 16.88±5.23 respectively, p<0.05). In the non-diabetic group there was a

significant difference of depression level among sexes (men 8.79±7.70 vs

women 13.43±12.35, p<0.05). However, there was no difference of dementia

levels among men and women. CRP circulating levels were correlated with

dementia (r=0.487, p<0.05), while no association was found between CRP

and depression. In diabetics, no relation between dementia/depression and

gender or CRP levels was established.

Conclusions:

ESRD dialysis patients suffer from moderate depression and

dementia. In those patients, depression is closely related with the presence

of diabetes. In non-diabetic dialysis patients we found a strong association

of female gender and depression status and high inflammatory status with

dementia.

Aikaterini Nouri has completed her MSc at the age of 25

years fromAlexander Technological Educational Institute

of Thessaloniki and post nursing studies also from Alex-

ander Technological Educational Institute of Thessaloni-

ki. She is editor of essay with title “The relation between

diabetes and dementia for patients undergoing dialysis”.

At the 9th European nursing conference which held in

Heraklion, Crete, Greece, she has presented a diabetic

related essay.

[email protected]

BIOGRAPHY