mass-spectrometry-congress-2019-scientifictracks

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May 20-21, 2019 | Rome, Italy

OF EXCELLENCE

IN INTERNATIONAL

MEETINGS

YEARS

Journal of Chemical Technology and Applications | Volume 3

MASS SPECTROMETRY,

PROTEOMICS AND POLYMER CHEMISTRY

International Conference on

Mass Spectrometry Congress 2019

METABOLOMICS PROFILES OF AUTISTIC CHILDREN’S URINE REVEALS ALTERED DOPA-

MINE AND NORADRENALINE LEVELS

Federica Gevi, Fanelli Giuseppina, Antonio Belardo, Sara Rinalducci

and

Timperio Anna Maria

University of Tuscia, Italy

utism spectrum disorders (ASDs) are a group of neurodevelopmental disorders consisting of a delayed or

altered language development and difficulties in social interactions. Beside clinical and social tests, met-

abolic abnormalities are frequently associated with ASD and their knowledge could help clinicians to provide

earlier and more reliable diagnosis. A considerable number (16,704) of urinary altered metabolites were re-

corded in autistic children, with 222 displaying the largest differences (p-value≤0.05 and fold change ≥1.5)

between young ASD children and controls. Several altered metabolic pathways have been implicated in the

disease, such as tryptophan, purines and pyrimidine’s; however, in this paper, altered level of the most import-

ant neurotransmitters have been discussed. The highest levels of dopamine and its metabolite, homovanillic

acid, indicated a dopamine β-hydroxylase enzyme block, probably due to presence of 4-cresol together with

a higher level of vitamin C, all revealed in the urine of autistic children. Moreover, the incorrect synthesis of

the active form of vitamin B6, pyridoxal-5’-phosphate was also detected, which is an essential co-factor for the

biotransformation of glutamate into GABA. The accumulation of glutamate and lower concentrations of GABA

were found in all of the autistic children examined.

Federica Gevi et al., J Chem Tech App 2019, Volume 3

Federica Gevi has completed her PhD in cellular biology at University of Tuscia, Italy. Currently she is a research RTDa of Tuscia Uni-

versity, Italy. She has 10 years of experience in the field of mass spectrometry-HPLC (MALDI TOF, Orbitrap, Q-TOF, amaZon ETD) in

protein identification, metabolomic and lipidomic characterizations in various biological samples. She has 23 publications that have

been cited over 300 times and her publication H-index is 10.

BIOGRAPHY