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Cell and Gene Therapy 2018 & Clinical Microbiology Congress 2018 Biomedical Research | ISSN: 0976-1683 | Volume 29
S e p t e m b e r 1 0 - 1 1 , 2 0 1 8 | D u b l i n , I r e l a n d
alliedacademies Joint Event on
CLINICAL AND MEDICAL MICROBIOLOGY
CELL AND GENE THERAPY
&
World Congress on
International Conference on
Ghada Mohammad Al-Ashmawy et al., Biomed Res 2018, Volume 29 | DOI: 10.4066/biomedicalresearch-C3-007
DOPAMINERGIC AGONISTS IMPROVE
OBESITY BY ITS ACTION ON LIPID
PROFILES AND LEPTIN
Ghada Mohammad Al-Ashmawy1, Eman Gouda Khedr 1
and Abla Ebeed2
1Tanta University, Egypt
2Delta University, Egypt
Background: The efficacy of a non-prescription drug to support weight
loss programs has yet to be compared. This clinical trial investigates the
comparability of the lipase inhibitor orlistat and the dopaminergic agonist
bromocriptine.
Methods: 75 obese females were randomized into three groups according to
treatment received; obese control group (OC, n=25), orlistat group (OR, n=25,
120 mg capsules, three times a day) and bromocriptine group (OB, n=25, 20
mg tablet, once a day). This prospective observational study was conducted
with norm caloric diet for eight weeks. Serum concentration of leptin and lipid
profile were measured, along with Body Mass Index (BMI) at baseline and
after the study.
Results: Bromocriptine treatment (OB) caused an increase in serum leptin
concentration compared to OC and OR groups (ANOVA, p<0.01). Beneficial
changes in anthropometric and BMI values were observed following orlistat
and bromocriptine administration with the greatest advantage seen in the OB
group.
Conclusions: Beneficial effects were observed on weight loss, and body
composition in all examined groups, with the greatest advantage on serum
leptin being associated with the bromocriptine treatment. We find these
strategies more promising for the treatment of obesity and its related
complications in obese women.
Ghada Al-Ashmawy is currently working in Tanta
University, Egypt.
BIOGRAPHY