analytical-chemistry-2019-keynote

Analytical Chemistry 2019

Page 13

November 20-21, 2019 | Berlin, Germany

OF EXCELLENCE

IN INTERNATIONAL

MEETINGS

YEARS

ANALYTICAL CHEMISTRY AND

CHROMATOGRAPHY METHODS

International Conference on

at 1-10fg loads. GC-Mini™ can do everything that 3Q and QTOF can do, and provides many other analytical opportunities: Re-

cording of panoramic (full mass) spectra. This provides non-filtered complete information, where post-analysis may be either

choosing MRM channels of 3Q methods, or flexibly selecting channels with reduced matrix interference (Judged by relative

peaks intensity and by retention time correlation of the traces); MRMmethods for 3Q could be verified, adjusted or developed

to overcome the method variations, caused by matrix or chromatography variations; Accurate masses of fragments improve

the identification confidence andmay be serving as a court proof; data can be treated after acquisitionwhen searching for un-

knowns; Identification and detection limits improve vs 3Q, since GC-MRTOF records fragments produced within the EI source

and avoid losses associated with parent selection and fragmentation. Though the GC-MRTOF instrument may be potentially

extended to GCxGC-TOF or to GC-Q-TOF, author do not see this as beneficial: GC-MRTOF already provides strong specificity

to separate low fg traces within complex matrices; GCxGC would further improve specificity, but would slow down analyses;

GC-Q-TOF would also improve specificity but would deteriorate LOD and LOQ with selection of single precursor and by split-

ting the precursor intensity into multiple fragments. The talk will present on the analysis of matrix composition and analytical

examples of GC-MRTOF analyses within complex matrices.

Journal of Chemical Technology and Applications | Volume 3