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ANALYTICAL CHEMISTRY AND
CHROMATOGRAPHY METHODS
2
nd
International Conference on
Analytical Chemistry 2019
Journal of Chemical Technology and Applications | Volume 3
QSAR AND MOLECULAR MODELING STUDIES ON CALCIUM CHANNEL BLOCKERS: A
COMPREHENSIVE NOTE
Satya P Gupta
Meerut Institute of Engineering and Technology, India
C
alcium channel blockers (CCBs) have got potential therapeutic uses against several cardiovascular and
non-cardiovascular diseases, such as angina, hypertension, arrhythmias, asthma, dysmenorrhea, prema-
ture labor, cancer, epilepsy, glaucoma etc. The three principal structural classes of compounds have been found
to act as potent calcium channel blockers and they are phenylalkylamines, 1, 4-dihydropyridines (DHPs) and
benzodiazepines. Recently, a few more classes of CCBs have been studied. All these classes of CCBs have been
found to be the most effective drugs against vasospastic angina. These drugs selectively inhibit Ca
2+
influx into
heart muscles by blocking slow inward channels for Ca
2+
or inhibit Ca
2+
influx into vascular smoothmuscles. The
result is negative inotropism of smooth muscle relaxation, which is translated into hypotension. Author intend
to present a comprehensive review, including the most recent studies, on quantitative structure-activity rela-
tionship (QSAR) and molecular modeling studies on all kinds of CCBs. These studies lead to highlight the essen-
tial structural features and physicochemical properties that the compounds should possess to act as potential
CCBs. These studies also describe vividly the mechanism of interaction of CCBs with the calcium channel. These
studies provide the ways to find new more potent calcium channel blockers to be therapeutically more useful.
J Chem Tech App 2019, Volume 3
Accepted Abstracts