Page 19
November 20-21, 2019 | Berlin, Germany
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ANALYTICAL CHEMISTRY AND
CHROMATOGRAPHY METHODS
2
nd
International Conference on
Analytical Chemistry 2019
TOWARDS SEPARATION OF TEN THOUSAND COMPOUNDS WITH COMPREHENSIVE
MULTIDIMENSIONAL GAS
Chadin Kulsing
Chulalongkorn University, Thailand
M
ultidimensional gas chromatography (MDGC) is a high-performance separation technique with enhanced
peak capacity for analysis of multi-component samples such as petroleum, essential oils, food, beverag-
es, pharmaceutical and environmental. Hyphenation with mass spectrometry (MS) provides high confidence
identification of several hundred volatiles within a single analysis. In this presentation, experimental design,
instrumental and data analysis approaches in MDGC-MS comprising a range of comprehensive multiple heart-
cut (H/C) and comprehensive two-dimensional GC (GCXGC) techniques will be demonstrated. A special focus
is on the system employing a micro fluidic device called Deans Switch to perform comprehensive H/C MDGC
with different H/C windows and number of injections. Data analysis approaches will be presented so that the
experimental results can be represented as contour plots and evaluated according to peak capacity and the
number of separated peaks. To this end, the ‘continuum in MDGC’ technology can be established via plots of
analysis time vs separation performance. It will also be illustrated that this simple system can offer up to 10,000
analyte peak capacity which is ~10 times compared with that provided by conventional GC×GC. This work
describes a proof of theoretical concept with simple configuration for effective practical application, making
valuable contribution to high resolution chromatography research.
J Chem Tech App 2019, Volume 3
Accepted Abstracts
Journal of Chemical Technology and Applications | Volume 3