Research in Clinical Dermatology

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Mini Review - Research in Clinical Dermatology (2023) Volume 6, Issue 4

The science behind itching and how to find relief

Wen lin *

Center for Brain Science, Institutes of Brain Science, Shanghai Medical College, Fudan University, Shanghai 200032, China

*Corresponding Author:
Wen lin
Center for Brain Science, Institutes of Brain Science
Shanghai Medical College, Fudan University
Shanghai 200032, China

Received: 24-Jun-2023, Manuscript No. AARCD-23-110296; Editor assigned: 26- Jun -2023, PreQC No. AARCD-23-110296 (PQ); Reviewed: 11- Jul-2023, QC No. AARCD-23-110296; Revised: 13- Jul-2023, Manuscript No. AARCD-23-110296 (R); Published: 24- Jul-2023, DOI: 10.35841/aarcd-6.4.151

Citation: The science behind itching and how to find relief. Res Clin Dermatol. 2023;6(3):151

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Itching, that irritating sensation that prompts you to scratch, is a universal experience. From a mosquito bite to a healing wound, the urge to scratch an itchy spot can be overwhelming. But have you ever wondered what causes itching and how you can find relief? Delving into the science behind itching can provide valuable insights into this common yet intriguing phenomenon. Itching, scientifically known as pruritus, is a complex interaction between the nervous system, skin, and brain. It begins with the activation of specialized nerve cells called itch receptors or pruriceptors located in the skin. These receptors respond to certain substances, such as histamine, which is released in response to allergens, insect bites, or skin irritants. When these receptors are stimulated, they send signals to the spinal cord and brain, triggering the sensation of itching [1].

Interestingly, the neural pathways that transmit itch signals are closely related to those for pain. This is why scratching can sometimes bring temporary relief — by causing pain, scratching essentially overrides the itch signal. However, scratching too much can lead to more itching due to the release of other compounds that perpetuate the cycle. Histamine is a key player in the itch-sensation connection. It is released by specialized cells called mast cells, which are part of the body's immune response. Histamine's main purpose is to defend the body against invaders, but it can also cause intense itching. Allergic reactions, such as those to pollen, certain foods, or insect bites, can trigger mast cells to release histamine, leading to a cascade of itchiness [2].

Histamine isn't the only factor responsible for itching. Dry skin, for instance, can lead to itchiness as the skin's protective barrier is compromised, allowing moisture to escape and irritants to penetrate. Skin conditions like eczema and psoriasis involve chronic inflammation that can result in persistent itching. Furthermore, psychological factors such as stress and anxiety can exacerbate itching, suggesting a strong mind-body connection. While scratching might provide momentary relief, it's not a long-term solution. Excessive scratching can damage the skin, making it more vulnerable to infections. Instead, consider these alternative approaches to find lasting relief: Keeping your skin well-hydrated can help prevent dryness and itching. Opt for fragrance-free moisturizers to avoid further irritation. Applying a cold compress to the itchy area can provide relief by numbing the nerve endings and reducing inflammation. Topical Treatments: Over-the-counter creams or ointments containing hydrocortisone or calamine can help soothe itchiness. However, consult a healthcare professional before using any new product. If your itching is due to an allergic reaction, antihistamines can be effective in reducing histamine release and alleviating the itch [3].

Since stress can worsen itching, practices like meditation, deep breathing, and mindfulness can have a positive impact on your overall well-being and itch perception. For chronic itching related to skin conditions, a dermatologist might prescribe stronger medications to manage inflammation and itchiness. Avoid Triggers: Identify and avoid triggers that cause itching. This could involve wearing natural fabrics, using hypoallergenic detergents, and using gentle skincare products. Engaging in activities that take your mind off the itch can help reduce the sensation. Engrossing yourself in a hobby, watching a movie, or spending time with loved ones can provide temporary relief [4].

While the peripheral itch pathway involves the activation of itch receptors in the skin, the central itch pathway takes the signal from the spinal cord to the brain. This pathway involves various brain regions, including the thalamus and the somatosensory cortex. The brain's role in itch perception is crucial, as it can modulate the intensity of the itch sensation. Moreover, neural connections between the brain's emotional canters and the itch pathway might explain why stress and anxiety can amplify itching. Understanding this intricate neural network could lead to innovative treatments targeting the central nervous system to alleviate itching [5].


The science behind itching is a fascinating interplay of nerves, skin cells, and chemical signals. Understanding the underlying mechanisms can empower you to manage and find relief from this uncomfortable sensation. While scratching might be instinctual, exploring alternative methods to soothe the itch will not only prevent skin damage but also contribute to your overall well-being. Whether it's through moisturizing, topical treatments, or relaxation techniques, taking a holistic approach can help you gain the upper hand in the battle against itching. If itching persists or becomes severe, consulting a medical professional is crucial to identify underlying conditions and receive appropriate treatment.


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