Hematology and Blood Disorders

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Conference Proceedings - Hematology and Blood Disorders (2021) Volume 4, Issue 2

The Role of Vaccination within the “One Health” Agenda

p>Michael James Francis


Assistant Professor, PhD EurProBiol CBiol FRSB HonAssocRCVS, BioVacc Consulting Ltd, Amersham, UK, Email: [email protected]

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The One Health agenda has been defined as “the integration effort of multiple disciplines working locally, nationally and globally to attaining optimal health for people, animals and the environment”. It recognises that there is a significant connection between the health of animals and that of humans, and the impact that they both have on the environment

Vaccines have a key role to play within this agenda since they can control disease transmission between animals and human, and have a significant impact on their shared environments. As a prophylactic measure they can prevent the emergence of disease and as an intervention they can restrict its spread. Indeed, several vaccines are targeted towards domesticated animals and livestock in order to prevent the disease in both animals and humans.

In addition, collaboration between animal and human health vaccine researchers offers the potential to advance the understanding of mutually relevant diseases and expand the translational approach to medicine. It is also interesting to observe that many new vaccine technologies often find their first application within veterinary medicine.

The world’s population has already exceeded 7.7 billion people in 2019 and it continues to grow. As a result of this geographical expansion the contact between human and animal habitats increases.

This introduces a greater risk of exposure to new zoonotic disease causing pathogens. Advancing technologies and science-based evidence are improving our awareness, knowledge and understanding of the interdependency of the health of humans and animals, and their environments. This presentation will discuss how there is a clear association between the One Heath agenda, vaccination and the development of improved vaccines.

Selected Publications

Francis, M.J., Hastings, G.Z., McGinn, B., Syred, A., Rowlands, D.J. and Brown, F. Non-responsiveness to a foot-and-mouth disease virus peptide overcome by addition of foreign helper T cell determinants.
Nature, 1987, 330, 168-170.

Hastings, G.Z., Speller, S.A. and Francis, M.J. Neutralizing antibodies to human rhinovirus produced in laboratory animals and humans that recognise a linear sequence from VP2. Journal of General Virology, 1990, 71, 3055-3059.

Crouch, C.F., Oliver, S., Hearle, D.C., Buckley, A.J., Chapman, A.J and Francis, M. J. Lactogenic immunity following vaccination of cattle with bovine coronavirus. Vaccine, 2001, 19, 189-196.

Crouch, C.F., Andrews, S.J., Ward, R.G. and Francis, M.J. Protective efficacy of a live attenuated anticoccidial vaccine administered to day old chickens. Avian Pathology, 2003, 32, 297-304.

Francis, M.J. Vaccination for One Health. International Journal of vaccines and Vaccination, 2017, 4(5): 00090.

Francis, M.J. Recent Advances in Vaccine Technologies. Veterinary Clinics of North America: Small Animal Practice, 2018, 48, 31-241.

Stedman, A., Wright, D., Wichgers, P.J., Clark, M., Hill, A.V.S., Gilbert, S.C., Francis, M.J., van Keulen, L., Kortekaas, J., Charleston, B and Warimwe, G.M. Safety and efficacy of ChAdOx1 RVF Vaccine
against Rift Valley fever in pregnant sheep and goats. Npj Vaccines, 2019, 44, 1-8

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