Review Article - Journal of Neurology and Neurorehabilitation Research (2025) Volume 10, Issue 2
The Role of Aerobic Exercise in Enhancing Neuroplasticity
Ahmed Al-Hassan*Department of Neurology, King Fahd Medical Research Center, Saudi Arabia.
- *Corresponding Author:
- Ahmed Al-Hassan
Department of Neurology
King Fahd Medical Research Center, Saudi Arabia.
E-mail: ahmed.alhassan@kfmc.sa
Received: 03-Apr-2025, Manuscript No. JNNR-25-169115; Editor assigned: 04-Apr-2025, PreQC No. JNNR-25-1691155(PQ); Reviewed: 18-Apr-2025, QC No JNNR-25-1691155; Revised: 21-Apr-2025, Manuscript No. JNNR-25-1691155(R); Published: 28-Apr-2025, DOI:10.35841/aajnnr-10.2.259
Citation: Al-Hassan A. The role of aerobic exercise in enhancing neuroplasticity. J Neurol Neurorehab Res. 2025;10(2):259.
Introduction
Aerobic exercise has gained significant attention in neuroscience and rehabilitation research for its capacity to enhance neuroplasticity, the brain’s ability to reorganize and form new neural connections in response to learning, experience, and injury. Neuroplasticity underlies critical processes such as skill acquisition, memory formation, and recovery from neurological damage. Engaging in regular aerobic activities like brisk walking, cycling, swimming, or running stimulates numerous physiological changes that benefit brain structure and function. These activities increase blood flow, deliver essential nutrients and oxygen to neural tissue, and promote the release of neurotrophic factors such as brain-derived neurotrophic factor (BDNF), which supports the survival and growth of neurons. The cumulative effects of these mechanisms contribute to improved cognitive performance, emotional well-being, and resilience against neurodegenerative conditions [1].
Research has shown that aerobic exercise can directly influence structural changes in the brain, including increased gray matter volume in regions involved in memory, learning, and executive function. Functional changes are also observed, such as enhanced connectivity within neural networks responsible for attention and problem-solving. In both healthy individuals and those with neurological conditions, aerobic exercise appears to facilitate synaptic plasticity, enabling neurons to communicate more effectively. This is particularly relevant for aging populations, where natural declines in neuroplasticity contribute to cognitive impairment. Studies indicate that regular aerobic activity may slow or even reverse age-related cognitive decline, supporting brain health across the lifespan. Importantly, these benefits are not limited to high-intensity training—moderate-intensity exercise sustained over time can also produce meaningful neuroplastic changes [2].
The neurochemical effects of aerobic exercise play a central role in its ability to enhance neuroplasticity. Exercise increases levels of BDNF, which is critical for synapse formation, dendritic growth, and overall neural adaptability. Elevated levels of neurotransmitters such as dopamine, serotonin, and norepinephrine also contribute to improved mood, motivation, and cognitive flexibility, creating an optimal environment for learning and memory consolidation. Additionally, aerobic exercise reduces inflammation and oxidative stress in the brain, factors that can impair neuroplasticity and contribute to neurodegenerative disease progression. These neurochemical changes help explain why individuals who engage in regular aerobic exercise often exhibit better cognitive performance, improved emotional regulation, and greater capacity for skill learning [3].
The role of aerobic exercise in neurorehabilitation is increasingly recognized, particularly for individuals recovering from stroke, traumatic brain injury, or other neurological conditions. Incorporating aerobic exercise into rehabilitation programs can prime the brain for more effective participation in physical, occupational, and cognitive therapies. For example, performing moderate-intensity aerobic activity before engaging in skill-based training can increase cortical excitability and improve the brain’s responsiveness to rehabilitation exercises. This “priming” effect may accelerate recovery, enhance functional outcomes, and promote long-term maintenance of gains. Aerobic exercise also supports cardiovascular fitness, which in turn improves cerebral perfusion and overall brain health, further reinforcing neuroplastic processes [4].
Despite its clear benefits, there are practical challenges to implementing aerobic exercise programs aimed at enhancing neuroplasticity. Factors such as age, baseline fitness level, medical comorbidities, and personal preferences must be considered when designing an exercise regimen. Safety concerns, particularly for individuals with cardiovascular risks or mobility impairments, may limit participation unless programs are carefully tailored and supervised. Motivation and adherence can also be obstacles, as sustained benefits require ongoing commitment to regular activity. Furthermore, research continues to explore the optimal type, intensity, and duration of aerobic exercise needed to maximize neuroplastic changes, as these parameters may vary depending on individual circumstances and goals. Addressing these challenges will be crucial to ensuring that aerobic exercise becomes a widely accessible and effective tool for enhancing brain health [5].
Conclusion
Aerobic exercise offers a powerful, non-invasive means of enhancing neuroplasticity, benefiting both healthy individuals and those recovering from neurological injury or disease. By stimulating structural and functional changes in the brain, promoting the release of neurotrophic factors, and creating a neurochemically supportive environment, aerobic exercise strengthens the brain’s capacity to adapt, learn, and recover. While challenges remain in tailoring and sustaining exercise programs, the growing body of evidence underscores its importance as a cornerstone of cognitive health and rehabilitation. As research continues to refine best practices, aerobic exercise stands out as an accessible and impactful strategy for optimizing brain function and fostering resilience throughout life.
References
- Saccà F, Pane C, Espinosa PE, et al. Efficacy of innovative therapies in myasthenia gravis: a systematic review, meta?analysis and network meta?analysis. Eur J Neurol. 2023;30(12):3854-67.
- Tsoi MR, Lin JH, Patel AR. Emerging therapies for transthyretin amyloidosis. Curr Oncol Rep. 2023;25(6):549-58.
- Kirschner J. Postnatal gene therapy for neuromuscular diseases–opportunities and limitations. J. Perinat. Med. 2021;49(8):1011-5.
- Hänselmann A, Berliner D, Bauersachs J, et al. Cardiac amyloidosis—interdisciplinary approach to diagnosis and therapy. Herz. 2022;47(4):324-31.
- Nuvolone M, Girelli M, Merlini G. Oral therapy for the treatment of transthyretin-related amyloid cardiomyopathy. Int J Mol Sci. 2022;23(24):16145.
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