Journal of Orthopedic Surgery and Rehabilitation

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +1 (202) 780-3397

Rapid Communication - Journal of Orthopedic Surgery and Rehabilitation (2023) Volume 7, Issue 3

The Growing Challenge of Degenerative Diseases and Treating Chronic Neurological Conditions

Ruth Asch*

Department of Orthopedic Surgery, University of Greenwich, England, United Kingdom

*Corresponding Author:
Ruth Asch
Department of Orthopedic Surgery,
University of Greenwich,
England, United Kingdom

Received:19-Apr-2023, Manuscript No. AAOSR-23-98300; Editor assigned: 22-Apr-2023, PreQC No. AAOSR -23-98300 (PQ); Reviewed:08-May-2023, QC No. AAOSR -23-98300; Revised:11-May-2023, Manuscript No. AAOSR -23-98300 (R); Published:18-May-2023, DOI:10.35841/ aaosr-7.3.145

Citation: Asch R. The growing challenge of degenerative diseases and treating chronic neurological conditions. J Ortho Sur Reh. 2023;7(3):145

Visit for more related articles at Journal of Orthopedic Surgery and Rehabilitation


Degenerative diseases, also known as neurodegenerative diseases, refer to a group of chronic and progressive conditions that affect the function and structure of the nervous system, including the brain, spinal cord, and peripheral nerves. These diseases often cause a gradual deterioration of the affected areas of the nervous system, leading to a wide range of symptoms that can severely impact a person's quality of life. There are many types of degenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis (ALS), to name a few. While these diseases may differ in their specific symptoms and underlying mechanisms, they share a common feature of gradually worsening symptoms over time [1].

The causes of degenerative diseases are not yet fully understood, but research suggests that genetic, environmental, and lifestyle factors may all play a role. For example, mutations in certain genes have been linked to an increased risk of developing certain degenerative diseases, while exposure to toxins and other environmental factors may also contribute to disease development. Despite ongoing research efforts, there is currently no cure for most degenerative diseases, and treatment options are limited to managing symptoms and improving quality of life. In some cases, medications may be prescribed to alleviate symptoms such as tremors or muscle stiffness, while physical therapy, occupational therapy, and speech therapy may also be helpful for managing specific symptoms [2].


One of the most well-known degenerative diseases is Alzheimer's disease, which is characterized by a progressive decline in cognitive function and memory. While the exact cause of Alzheimer's disease is still unknown, research suggests that a buildup of abnormal proteins in the brain, such as amyloid and tau, may play a role in the disease's development. Parkinson's disease, on the other hand, is characterized by tremors, stiffness, and difficulty with movement. Parkinson's disease occurs when the brain cells that produce dopamine, a neurotransmitter involved in movement and coordination, begin to die off. While the underlying cause of Parkinson's disease is not fully understood, genetic and environmental factors may both play a role [3].


Huntington's disease is a rare genetic disorder that affects the nervous system, leading to a range of symptoms such as involuntary movements, cognitive decline, and behavioral changes. Huntington's disease is caused by a mutation in the huntingtin gene, which leads to the production of a toxic protein that damages brain cells over time. Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a degenerative disease that affects the nerve cells responsible for controlling voluntary muscles. Over time, ALS leads to muscle weakness and wasting, making it difficult to perform even simple movements such as walking or speaking. While the underlying cause of ALS is not fully understood, researchers believe that a combination of genetic and environmental factors may contribute to disease development [4].


Degenerative diseases are a group of chronic and progressive conditions that affect the function and structure of the nervous system. While there is currently no cure for most degenerative diseases, ongoing research efforts are aimed at understanding the underlying causes of these conditions and developing new treatment options to improve quality of life for those affected by these devastating diseases. Living with a degenerative disease can be challenging, not only for the individual affected but also for their family and caregivers. These diseases can significantly impact a person's ability to carry out daily activities and may also lead to a loss of independence. As such, it is essential for individuals living with degenerative diseases to receive comprehensive care that addresses not only their physical needs but also their emotional and social wellbeing.

For example, in addition to medical treatment, individuals living with degenerative diseases may benefit from counseling or support groups to help them cope with the emotional challenges of their condition. They may also benefit from assistive devices and home modifications that can help them maintain their independence and improve their quality of life. In recent years, advances in technology have also opened up new possibilities for improving the care of individuals with degenerative diseases.

For example, wearable devices and mobile apps can help individuals track their symptoms, monitor their medications, and communicate more effectively with their healthcare providers. Telemedicine, which involves remote consultations with healthcare providers via video or phone, can also be an effective way to provide care to individuals with degenerative diseases who may have difficulty traveling to in-person appointments [5].


Finally, while there is currently no cure for most degenerative diseases, there is ongoing research into new treatments and potential cures. For example, researchers are exploring the potential of gene therapy to treat genetic forms of degenerative diseases, while stem cell therapy is being investigated as a way to regenerate damaged tissues in the nervous system.



Congenital disorders are a complex group of conditions that can have a significant impact on a child’s life. Early diagnosis and treatment are important for helping children with these conditions achieve their full potential. With the right supports and resources, children with congenital disorders can lead healthy and fulfilling lives and make valuable contributions to their communities.


  1. Cho KI, Yoon D, Qiu S, et al.Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.Disease Models & Mechanisms. 2017;10(5):559-79.
  2. Google Scholar

  3. Cooper AA, Gitler AD, Cashikar A, et al.α-Synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models.Science. 2006;313(5785):324-8.
  4. Google Scholar

  5. Couthouis J, Hart MP, Shorter J, et al.A yeast functional screen predicts new candidate ALS disease genes.Proc Natl Acad Sci. 2011;108(52):20881-90.
  6. Indexed at, Google Scholar, Cross Ref

  7. Elden AC, Kim HJ, Hart MP, et al.Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS.Nature. 2010;466(7310):1069-75.
  8. Indexed at, Google Scholar,Cross Ref

  9. Fernández-Trapero M, Espejo-Porras F, Rodríguez-Cueto C, et al.Upregulation of CB2 receptors in reactive astrocytes in canine degenerative myelopathy, a disease model of amyotrophic lateral sclerosis.Disease models & mechanisms. 2017;10(5):551-8.
  10. Indexed at, Google Scholar, Cross Ref

Get the App