Otolaryngology Online Journal

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +44 151 808 1136

Opinion Article - Otolaryngology Online Journal (2022) Volume 12, Issue 2

Simultaneous Discrete Intradiploic and Intracerebral Extraordinary Epidermis Cysts: Possible Embryological Theories

Lobsang Rampa*

Department of Otorhinolaryngology, Mohammed VI University of Health Sciences, Casablanca, Morocco

*Corresponding Author:
Rampa L
Department of Otorhinolaryngology
Mohammed VI University of Health Sciences
Casablanca, Morocco
E-mail:lobsangdh@ hotmail.com

Received: 03-Feb-2022, Manuscript No. JORL-22-259; Editor assigned: 05-Feb-2022, PreQC No. JORL-22-259 (PQ);Reviewed: 18-Feb-2022, QC No. JORL-22-259; Revised: 21-Feb-2022, Manuscript No. JORL-22-259 (R); Published: 28-Feb-2022, DOI: 10.35841/2250-0359.12.2.259

Visit for more related articles at Otolaryngology Online Journal

Epidermoid cysts are benign, slow-developing lesions that account for approximately 1% of all primary brain tumours. They normally arise inside the cerebellopontine attitude (40-50%) and parasellar regions. Intraparenchymal or intradiploic epidermoid cysts are uncommon, accounting for throughout the third week of embryogenesis, whilst intradiploic lesions occur whilst the entrapment occurs after neural tube closure [1].

But, the precise pathogenesis stays doubtful. The first case of intradiploic epidermoid cyst becomes reported by using Harvey Cushing in 1922. on account that then, a couple of case reviews have emerged, describing this rare entity that generally provides as slowly enlarging scalp lumps. Our patient presented with insidious symptoms of raised intracranial strain and become found to have concomitant 'white epidermoid' cysts, one intradiplopic and the other intracerebral. Interestingly, both lesions were of different consistencies, with the former being ordinarily semi-strong and granular, even as the latter turned into fluid in consistency. In 2008, Ichimura, et al. reported a case with a dumbbellshaped intracranial epidermoid cyst with extradural and intramural additives that displayed typical MRI capabilities. Intraoperative, they located that the 2 components were contiguous thru a dural defect. Even though there has been touch between the intradiploic and intradural epidermoid cysts in our patient's scans, both the lesions had been markedly exceptional in phrases of the CT and MRI capabilities [2].

Additionally, we did no longer pick out any dural disorder or direct conversation between the intradiploic and intradural epidermoid lesions in the course of surgery. We recommend that the lack of verbal exchange among the two epidermoid lesions could be because of a few theories. First, the entrapment of the ectodermal cells may also have passed off within both the diploe and the Sylvia fissure along not unusual radial traces of migration. it is recognised that embryological, the anterior part of the cranium which include the sphenoid bone constitutes the neurocranium which arises from neural crest cells. The pre-migratory neural crest cells shape the neural plate borders which separate non-neuroectodermal tissue from the neural plates. While the neural plates and neural crest cells from each aspect converge, the non-neuroectodermal tissue might have been trapped within the fusion points of the neural plate and neural crest cellular layers. The two concomitant lesions seen in our patient could have consequently arisen from this entrapment method, albeit at one of kind stages of neural tube closure. This theory may additionally support the formation of the two discrete epidermoid lesions with various proteinaceous contents in our patient's case. Alternatively, each epidermoid lesion could have been in the beginning linked via a dural disorder with subsequent healing or fibrosis due to inflammatory reactions from the cystic contents.

Consequently, the intradiploic epidermoid cyst underwent cycles of calcification and resorption, ensuing in a paste-like, semi-strong contents discovered intraoperative. Conversely, the walledoff and discrete intracerebral epidermoid aspect continued as thick viscous fluid contents, explaining the unique consistencies of the 2 epidermoid cysts. Iatrogenic or demanding ectodermal mobile implantation main to two discrete epidermoid cysts is a much less probably postulation for the reason that our patient had no earlier history of worrying head harm or invasive intracranial tactics [3].


  1. MacMahon P, Labak CM, Martin-Bach SE, Issawi A, Velpula K, et al. (2018) Glioblastoma formation in a recurrent intracranial epidermoid cyst: a case report.

    Indexed at, Google Scholar, Cross Ref

  2. . Jurc? AD, Kozma K, Ioana M, Strea?? I, Petche?i CD, et al. (2017) Morphological and genetic abnormalities in a Jacobsen syndrome. Rom J Morphol Embryol 58:1531-34.
  3. Indexed at, Google Scholar

  4. Huo CW, Caputo C, Wang YY (2018) Suprasellar keratinous cyst: a case report and review on its radiological features and treatment outcome. Surg Neurol Int.9:15–15.
  5. Indexed at, Google Scholar, Cross Ref

Get the App