Perspective - Journal of Clinical and Bioanalytical Chemistry (2022) Volume 6, Issue 6
Scientific progresses and hones of clinical and bioanalytical chemistry followed by analytical chemistry.
Department of Chemistry, Yildiz Technical University, Istanbul, Turkey
- *Corresponding Author:
- Notake Buse
Department of Chemistry, Yildiz Technical University
Received: 24-Nov-2022, Manuscript No. AAACBC-22-82325; Editor assigned: 26-Nov-2022, PreQC No. AAACBC-22-82325 (PQ); Reviewed: 10-Dec-2022, QC No. AAACBC-22-82325; Revised: 15-Dec-2022, Manuscript No. AAACBC-22-82325(R); Published: 22-Dec-2022, DOI: 10.35841/aacbc-6.6.130
Citation: Buse N. Scientific progresses and hones of clinical and bioanalytical chemistry followed by analytical chemistry. J Clin Bioanal Chem. 2022;6(6):130
The progress of analytical techniques and their application to pertinent medical and clinical problems are the most significant goals usually found in analytical and bioanalytical chemistry. In light of these factors, the current chapter's main focus is the development of sophisticated analytical methods employed in the medical industry. As an illustration, the enzyme N-acetylbeta-D-glucosaminidase (NAG) is a particular biomarker of acute kidney injury. A biomarker is a substance that is intentionally tested and calculated as a predictor of a pathogenic process, a normal biological process, or the pharmacological reactions to a therapeutic intervention.
Analytical, Bioanalytical, Biomarker, Clinical, Medical, N-Acetyl-Beta-D-Glucosaminidase.
Structure research on organs, cells, and organelles is no longer the main focus of biomedical research. The distribution and speciation of chemicals, the regulation of chemical processes, and the management of chemical environments are the three main issues that must be addressed in order to comprehend the body in health and disease today. Analytical chemists must take an active role in the entire process if they hope to see advancements in the profession. In this Feature Article, we evaluate the strides that have been made in understanding the chemistry of the body and discuss the fundamental gap between recent developments in analytical chemistry and their actual use in the biosciences. We pinpoint the obstacles that hamper chemists from making a greater impact in this field, and highlight key steps for moving forward .
Hence, successive measurements of urinary NAG may enhance its clinical use as an indicator of ongoing tubular injury. Hence, in order to obtain information for selective monitoring of biomarker, the development of a practical and valid analytical method is important. Experimentation is driven by the need to know more about the medical effects and safety features of the biologically active analyte. It is therefore more important to evaluate the information that is already available for that particular analyte and to quantify the level of uncertainty for the proposed technique .
Instrumental approaches are being extended most in medical and clinical analyses. Analytical chemists are faced with new hurdles as a result of the rapidly expanding interest in discovering physiologically active chemicals. The development of bioanalytical technology as a contemporary strategy for disease diagnosis and therapy has overcome these difficulties. A biological sample (blood-cerebrospinal fluid (CSF), serum, plasma, or urine, tissue, and skin) is collected, processed, stored, and subjected to an analysis as part of a bioanalytical method. The quantitative analysis of medicines and metabolites in biological samples can also be done using this technology. Because of this, the technologies employed for bioanalytical procedures differ depending on the type of analyte. Consequently, to determine the right technologies used in a bioanalytical method for the purpose of quantification of an analyte, the method validation is important. This procedure is termed as bioanalytical method validation .
The simplest unit in chemistry is the atom. It is made up of an electron cloud surrounding a dense core known as the atomic nucleus. The electron cloud is made up of negatively charged electrons that orbit the nucleus, whereas the nucleus is made up of positively charged protons and uncharged neutrons (together called nucleons). The protons positive charge and the negatively charged electrons' balance each other out in a neutral atom. The radius of an atom is roughly 10,000 times larger than its nucleus, yet the mass of a nucleon is approximately 1,836 times that of an electron, indicating that the nucleus is dense .
A compound is an unadulterated chemical substance made up of many elements. A compound's characteristics are rarely the same as those of its constituent parts. The International Union of Pure and Applied Chemistry establishes the norm for chemical nomenclature (IUPAC). The organic nomenclature system is used to name organic substances. The inorganic nomenclature system is used to provide the names for inorganic substances. When a compound contains more than one element, the electropositive and electronegative elements are separated into two classes. The Chemical Abstracts Service has also developed a system for indexing chemical compounds. Each chemical substance in this system has a unique identification number known as its CAS registry number .
The tiniest, indivisible unit of a pure chemical substance, a molecule has its own distinct set of chemical properties and the capacity to interact chemically with other molecules in a variety of ways. Nevertheless, this definition only applies to substances made of molecules, which is not the case for many substances. The majority of the time, molecules are made up of a collection of atoms that are joined by covalent bonds, making the structure electrically neutral and ensuring that all of the valence electrons are in pairs with other electrons, either in bonds or lone pairs.
- Wang K, Stenner C, Weissmüller J. A nanoporous gold-polypyrrole hybrid nanomaterial for actuation. Sens Actuators B Chem. 2017;248:622-9.
- Yan B, Wu Y, Guo L. Recent advances on polypyrrole electroactuators. Polymers. 2017;9(9):446.
- Brinker M, Dittrich G, Richert C, et al. Giant electrochemical actuation in a nanoporous silicon-polypyrrole hybrid material. Sci Adv. 2020;6(40):aba1483.
- Roschning B, Weissmüller J. Stress-charge coupling coefficient for thin-film polypyrrole actuators–Investigation of capacitive ion exchange in the oxidized state. Electrochim Acta. 2019;318:504-12.
- Song JH, Min SH, Kim SG, et al. Multi-functionalization Strategies Using Nanomaterials: A Review and Case Study in Sensing Applications. Int J Precis Eng Manuf Green Technol. 2021:1-25.