Asian Journal of Biomedical and Pharmaceutical Sciences

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Opinion Article - Asian Journal of Biomedical and Pharmaceutical Sciences (2023) Volume 13, Issue 102

Polymers with molecular imprints for medication distribution.

Carmen Steele *

Department of Molecular Biophysics and Biochemistry, Yale University, USA

*Corresponding Author:
Carmen Steele
Department of Molecular Biophysics and Biochemistry
Yale University

Received:26-Oct-2023, Manuscript No. AABPS-23-119403; Editor assigned:31-Oct-2023, PreQC No. AABPS-23-119403(PQ); Reviewed:14-Nov-2023, QC No. AABPS-23-119403; Revised:20-Nov-2023, Manuscript No. AABPS-23-11940 (R); Published:27-Nov-2023, DOI:10.35841/ aabps-13.102.206

Citation: Steele C. Polymers with molecular imprints for medication distribution. Asian J Biomed Pharmaceut Sci. 2023;13(102):206


The medical sector is always changing as scientists and researchers work to develop better drug delivery methods that will maximize therapeutic efficacy and minimize adverse effects. Using polymers with molecular imprints to distribute medications is one innovative approach that has drawn a lot of attention. By focusing on particular molecules and achieving precise control over drug release, this novel technique enhances patient outcomes [1, 2].

A family of artificial materials known as molecularly imprinted polymers, or MIPs, is made to resemble the composition and characteristics of natural binding sites or receptors. These polymers are made by a technique known as molecular imprinting, in which a polymer matrix is filled with holes or binding sites made by a template molecule, usually the medication of interest. Selective binding and recognition are made possible by these cavities because they complement the template molecule in both form and chemical makeup [3, 4].

Choosing the target molecule, which may be a medication, a particular active component, or a biomolecule, is the first step. The structural properties of the template molecule must be clearly established. A polymer matrix is made by combining different types of monomers and cross-linking agents. The polymerization process is started when the template molecule is added to this mixture. Following polymerization, the template molecule is eliminated, leaving behind binding sites or holes that exactly match the chemical composition and form of the template. The appropriate medication or active ingredient can be put into the MIPs, and it will bind within the imprinted cavities selectively [5, 6].

One of MIPs' most important benefits is their capacity to distribute drugs in a targeted manner. Drug release is precisely facilitated at the intended site of action by the imprinted cavities, which are specifically designed to recognize and bind to the drug. MIPs can improve a drug's therapeutic efficacy by enhancing its release profile. This guarantees that the medication is released at the appropriate time, location, and quantity, enhancing patient results and minimizing side effects. By designing MIPs to release medications over an extended length of time, the necessity for regular dosage can be minimized. Patients who require long-term drug regimens will benefit most from this [7, 8].

MIPs have the ability to selectively transport chemotherapeutic drugs to tumor locations, thereby mitigating harm to healthy cells while also targeting cancer cells. MIPs can be employed in diabetes to develop insulin delivery systems that react to blood glucose levels and release insulin only when required. By targeting particular bacterial strains with antibiotic delivery methods, MIPs can lower the likelihood of antibiotic resistance. By enabling the regulated and prolonged delivery of analgesic medications, MIPs can be used in pain management [9, 10].


A significant development in the pharmaceutical industry is the distribution of medications using polymers with molecular fingerprints. MIPs have the potential to decrease toxicity and side effects while improving the therapeutic results of a variety of drugs by providing precise and targeted drug delivery. We may anticipate the creation of novel and inventive medication delivery methods that will advance medicine and better patients' lives everywhere as researchers continue to hone and broaden this technology.


  1. Puoci F, Iemma F, Muzzalupo R, et al. Spherical molecularly imprinted polymers (SMIPs) via a novel precipitation polymerization in the controlled delivery of sulfasalazine. Macromole Biosci. 2004;4(1):22-6.
  2. Indexed at, Google Scholar, Cross Ref

  3. Zhang H, Ye L, Mosbach K. Non?covalent molecular imprinting with emphasis on its application in separation and drug development. J Mole Reco Interdisci J. 2006;19(4):248-59.
  4. Indexed at, Google Scholar, Cross Ref

  5. Cheong WJ, Yang SH, Ali F. Molecular imprinted polymers for separation science: A review of reviews. J Separa Sci. 2013;36(3):609-28.
  6. Indexed at, Google Scholar, Cross Ref

  7. White CJ, Byrne ME. Molecularly imprinted therapeutic contact lenses. Expert Opini Drug Deliver. 2010;7(6):765-80.
  8. Indexed at, Google Scholar, Cross Ref

  9. Zaidi SA. Molecular imprinting polymers and their composites: A promising material for diverse applications. Biomat Sci. 2017;5(3):388-402.
  10. Indexed at, Google Scholar, Cross Ref

  11. Tashakori-Sabzevar F, Mohajeri SA. Development of ocular drug delivery systems using molecularly imprinted soft contact lenses. Drug Develop Indust Pharm. 2015;41(5):703-13.
  12. Indexed at, Google Scholar, Cross Ref

  13. Byrne ME, Oral E, Zachary Hilt J, et al. Networks for recognition of biomolecules: molecular imprinting and micropatterning poly (ethylene glycol)?Containing films. Polyme Adva Technologies. 2002;13(10?12):798-816.
  14. Indexed at, Google Scholar, Cross Ref

  15. Gu Z, Dong Y, Xu S, et al. Molecularly imprinted polymer?based smart prodrug delivery system for specific targeting, prolonged retention, and tumor microenvironment?triggered release. Angewandte Chemie. 2021 Feb 1;133(5):2695-9.
  16. Indexed at, Google Scholar, Cross Ref

  17. BelBruno JJ. Molecularly imprinted polymers. Chem Rev. 2018;119(1):94-119.
  18. Google Scholar

  19. Arabi M, Ostovan A, Li J, et al. Molecular imprinting: green perspectives and strategies. Advanced Materials. 2021 Jul;33(30):2100543.
  20. Indexed at, Google Scholar, Cross Ref

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