Current Trends in Cardiology

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +1 (202) 780-3397

Short Communication - Current Trends in Cardiology (2023) Volume 7, Issue 12

Overview of pediatric heart transplant

Meral Kay?kcioglu *

Department of Cardiology, Ege University, Turkey.

*Corresponding Author:
Meral Kay?kcioglu
Department of Cardiology
Ege University

Received:30-Nov-2023,Manuscript No. AACC-23-128822; Editor assigned:02-Dec-2023,PreQC No. AACC-23-128822(PQ); Reviewed:17-Dec-2023,QC No. AACC-23-128822; Revised:22-Dec-2023, Manuscript No. AACC-23-128822(R); Published:29-Dec-2023,DOI:10.35841/aacc-7.12.229

Citation:Kay?kcioglu M. Overview of pediatric heart transplant. Curr Trend Cardiol. 2023;7(12):229 .

Visit for more related articles at Current Trends in Cardiology


Pediatric heart transplant is a remarkable medical procedure that offers a lifeline to children suffering from severe heart conditions that cannot be treated effectively through other means. This complex and emotionally charged procedure involves replacing a child's failing heart with a healthy donor heart. While it is a last-resort option, pediatric heart transplant has saved countless young lives and continues to advance, offering hope to families facing the unimaginable challenges of childhood heart disease.Heart disease can affect individuals of all ages, including children. While some congenital heart defects can be corrected through surgery or managed with medications, there are cases where the heart becomes so damaged or diseased that it can no longer function effectively. This situation is often referred to as end-stage heart failure, and it can lead to life-threatening complications.[1,2].

Children suffering from end-stage heart failure face a bleak future without intervention. They may experience debilitating symptoms such as severe fatigue, shortness of breath, and limited physical activity, all of which can significantly impact their quality of life. Moreover, their life expectancy is severely compromised, making pediatric heart transplant a necessary option for those facing this dire circumstance.Evaluation: The journey toward pediatric heart transplant begins with a thorough evaluation of the child's medical history and current condition. A team of specialists, including cardiologists, transplant surgeons, and social workers, assesses the child's physical and emotional health to determine if they are a suitable candidate for transplantation [3,4].

Once a child is deemed eligible for a heart transplant, they are placed on a national or regional transplant waiting list, administered by organizations like the United Network for Organ Sharing (UNOS) in the United States. Donor hearts are allocated based on factors such as blood type, body size, and medical urgency.Finding a Donor: Finding a suitable donor heart is a critical step in the transplant process. The wait for a compatible donor can be a challenging and emotionally draining experience for both the child and their family. In some cases, children may require temporary mechanical support devices, such as ventricular assist devices (VADs), while waiting for a donor heart. The Transplant Surgery: Once a matching donor heart becomes available, the child undergoes the transplant surgery. The procedure involves removing the recipient's damaged heart and replacing it with the healthy donor heart. Highly skilled transplant surgeons meticulously connect the new heart's blood vessels and ensure that it functions properly. Recovery and Post-Transplant Care: Following the surgery, the child is closely monitored in the intensive care unit (ICU) for several weeks. Immunosuppressive medications are prescribed to prevent rejection of the new heart, and regular check-ups and adjustments are made to the medication regimen. Pediatric transplant teams provide comprehensive post-transplant care, addressing physical, emotional, and psychological aspects of the recovery process.[5,6].


The success of pediatric heart transplant has improved significantly over the years due to advancements in surgical techniques, organ preservation methods, and immunosuppressive therapies. According to the Organ Procurement and Transplantation Network (OPTN) data, the one-year survival rate for pediatric heart transplant recipients in the United States is around 90%, while the five-year survival rate is approximately 75%. These statistics are encouraging and highlight the potential for children to lead healthy, fulfilling lives post-transplant.Despite its remarkable success, pediatric heart transplant is not without challenges and risks. The lifelong dependence on immunosuppressive medications to prevent organ rejection carries the risk of infection, complications, and side effects. Additionally, there is a limited supply of donor hearts, leading to prolonged waiting times, and some children may not receive a suitable match in time.[7,8].



Rejection of the transplanted heart remains a significant concern, and transplant recipients require regular monitoring and adjustment of their medication regimen to minimize this risk. The emotional toll on children and their families can be substantial, as they navigate the physical and psychological aspects of the transplant journey.Advancements in medical research and technology continue to shape the future of pediatric heart transplant. Some promising developments include. Artificial Hearts: Researchers are exploring the use of artificial hearts and mechanical assist devices to bridge the gap between heart failure diagnosis and transplant surgery. These devices can improve a child's quality of life while they wait for a donor heart.[



  1. Fiorina P. Impaired nocturnal melatonin excretion and changes of immunological status in ischaemic stroke patients. Lancet. 1996;347:692?
  2. Indexed at, Google scholar, Cross Ref

  3. Corna G. Polarization dictates iron handling by inflammatory and alternatively activated macrophages. Haematologica. 2010;95:1814?
  4. Indexed at, Google scholar, Cross Ref

  5. Das A. High?resolution mapping and dynamics of the transcriptome, transcription factors, and transcription co?factor networks in classically and alternatively activated macrophages. Front Immunol. 2018;9:22.
  6. Indexed at, Google scholar, Cross Ref

  7. Webb LM. Novel markers to delineate murine M1 and M2 macrophages. PLoS One. 2015;10:e0145342. 
  8. Indexed at, Google scholar, Cross Ref

  9. Das A. Monocyte and macrophage plasticity in tissue repair and regeneration. Am J Pathol. 2015;185:2596?
  10. Indexed at, Google scholar, Cross Ref

  11. Das BB. Current state of pediatric heart failure. Children. 2018;5(7):88.
  12. Indexed at, Google Scholar, Cross Ref

  13. Hsu DT. Lessons learned from the pediatric heart transplant study. Cong Heart Dis. 2006;1(3):54-62.
  14. Indexed at, Google Scholar, Cross Ref

  15. Kirk R. The first successful pediatric heart transplant and results from the earliest era. Pedi Trans. 2019;23(2):e13349.
  16. Indexed at, Google Scholar, Cross Ref

  17. Davies RR. Donor organ turn-downs and outcomes after listing for pediatric heart transplant. J Heart and Lung Trans. 2019;38(3):241-51.

  19. Dent CL. Transplant coronary artery disease in pediatric heart transplant recipients. J  Heart and Lung Trans. 2000;19(3):240-8.
  20. Indexed at, Google Scholar, Cross Ref


Get the App