Journal of Neurology and Neurorehabilitation Research

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Perspective - Journal of Neurology and Neurorehabilitation Research (2025) Volume 10, Issue 3

Innovative Approaches to Sensory Rehabilitation in Peripheral Neuropathy and Central Nervous System Disorders

Yuna Kim*

Department of Neurophysiology, Seoul National University, South Korea.

*Corresponding Author:
Yuna Kim
Department of Neurophysiology
Seoul National University, South Korea
E-mail: y.kim@snu.ac.kr

Received: 03-Jul-2025, Manuscript No. JNNR-25-171940; Editor assigned: 04-Jul-2025, PreQC No. JNNR-25-1719405(PQ); Reviewed: 18-Jul-2025, QC No JNNR-25-1719405; Revised: 21-Jul-2025, Manuscript No. JNNR-25-1719405(R); Published: 28-Jul-2025, DOI:10.35841/ aajnnr -10.3.268

Citation: Kim Y. Innovative approaches to sensory rehabilitation in peripheral neuropathy and central nervous system disorders. J Neurol Neurorehab Res. 2025;10(3):268.

Introduction

Sensory dysfunction significantly impacts patient quality of life and functional independence, particularly in conditions such as peripheral neuropathy and central nervous system (CNS) injuries. Impairments in tactile, proprioceptive, and pain perception often hinder rehabilitation progress and complicate motor recovery. Recent advances in neurorehabilitation highlight the importance of targeted sensory retraining to facilitate cortical and subcortical plasticity. By systematically engaging affected sensory modalities, clinicians can promote adaptive reorganization within somatosensory networks, improving perception and integration of sensory information essential for functional performance [1].

Techniques such as tactile discrimination training, proprioceptive exercises, and virtual reality–based sensory feedback have demonstrated efficacy in restoring sensory function. These interventions employ repeated, graded exposure to sensory stimuli, enhancing cortical representation and synaptic efficiency. For example, tactile stimulation of denervated skin areas can induce expansion of cortical maps in the primary somatosensory cortex, supporting functional recovery. Similarly, immersive virtual environments can provide controlled sensory input that encourages multisensory integration, facilitating both motor and cognitive gains [2].

Neuromodulation strategies complement traditional sensory rehabilitation by modulating cortical excitability and enhancing network responsiveness. Transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) applied to somatosensory regions have been shown to improve tactile discrimination and proprioceptive accuracy. These interventions potentiate the effects of active training by reinforcing adaptive neural circuits and reducing maladaptive plasticity. Combined with task-specific exercises, neuromodulation offers a promising avenue to accelerate sensory recovery and functional reintegration [3].

Pharmacological adjuncts may further support sensory rehabilitation. Agents targeting neurotrophic factors, ion channel function, or neurotransmitter balance can enhance synaptic plasticity and neural responsiveness. In patients with peripheral neuropathy, modulation of sodium and calcium channel activity can improve nerve conduction and facilitate relearning of sensory-motor tasks. Personalized approaches that integrate pharmacological support with behavioral and neuromodulatory interventions may optimize outcomes across diverse patient populations [4].

Despite these advances, challenges remain in achieving consistent, long-term sensory recovery. Patient-specific factors, including lesion location, severity of impairment, and comorbidities, influence responsiveness to therapy. Monitoring progress through neuroimaging and electrophysiological techniques can guide individualized treatment plans and inform adjustments over time. Interdisciplinary collaboration among neurophysiologists, therapists, and clinicians remains critical for translating experimental findings into practical, patient-centered sensory rehabilitation strategies [5].

Conclusion

Targeted sensory rehabilitation in peripheral neuropathy and CNS disorders promotes adaptive neural plasticity and functional reintegration. By combining graded sensory training, neuromodulation, and pharmacological support, clinicians can enhance perception, motor performance, and quality of life. Continued research and individualized approaches are essential to optimize outcomes and develop innovative therapies for sensory recovery.

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