Current Trends in Cardiology

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Perspective - Current Trends in Cardiology (2023) Volume 7, Issue 5

Hypercholesterolemia: A Comprehensive Guide to Diagnosis and Treatment

Yanman Zhou*

 Department of Endocrinology, Shandong University, Jinan, China

*Corresponding Author:
Yanman Zhou
Department of Endocrinology
Shandong University
Boston, United.

Received:28-Apr-2023, Manuscript No. AACC-23-97808; Editor assigned: 01-May-2023,PreQC No. AACC-23-97808(PQ); Reviewed:15-May-2023,QC No. AACC-23-97808; Revised:19-May-2023, Manuscript No. AACC-23-97808(R); Published:26-May-2023,DOI:10.35841/aacc-7.5.161

Citation: Zhou Y. Hypercholesterolemia: a comprehensive guide to diagnosis and treatment. J Cell Biol Metab. 2023;7(5):161

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Hypercholesterolemia is viewed as a standard gamble factor for cardiovascular sickness, affecting the actual myocardium, notwithstanding the improvement of atherosclerosis. Since hypercholesterolemia influences the worldwide heart quality articulation profile, among numerous different variables, it brings about expanded myocardial oxidative pressure, mitochondrial brokenness and irritation set off apoptosis, all of which might represent myocardial brokenness and expanded vulnerability of the myocardium to localized necrosis.


Familial hypercholesterolemia, Genetic testing, Cascade screening, Statins.


Hypercholesterolemia, also known as high cholesterol, is a medical condition that occurs when there is an excessive amount of cholesterol in the blood. Cholesterol is a type of lipid that is produced by the liver and is essential for various biological processes in the body, such as the production of hormones, cell membranes, and vitamin D. However, when the levels of cholesterol in the blood become too high, it can lead to the development of several health problems, including heart disease, stroke, and peripheral artery disease. Also, various trial and clinical investigations have uncovered that hypercholesterolemia may obstruct the cardio protective capability of molding instruments [1].

Albeit not completely explained, the hidden systems for the lost cardio protection in hypercholesterolemia creatures have been accounted for to include dysregulation of the endothelial NOS?cGMP, reperfusion injury rescue kinase, peroxynitrite?MMP2 flagging pathways, adjustment of ATP?sensitive potassium channels and apoptotic pathways. There are two types of cholesterol: low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol. LDL cholesterol is commonly referred to as "bad" cholesterol because it can build up in the walls of arteries, forming plaques that can lead to atherosclerosis a condition where arteries become narrowed and hardened [2].

On the other hand, HDL cholesterol is considered "good" cholesterol because it helps to remove excess cholesterol from the blood and transport it back to the liver for disposal. There are several factors that can contribute to high cholesterol levels in the blood. One of the most common causes is a diet that is high in saturated and trans fats, which are found in animal products, such as meat, dairy, and eggs, as well as in processed foods, such as baked goods and fried foods. Other risk factors for hypercholesterolemia include being overweight or obese, not getting enough exercise, smoking, and having a family history of high cholesterol or heart disease [3].

The symptoms of hypercholesterolemia are often not noticeable until the condition has progressed and caused significant damage to the arteries. In some cases, people may experience chest pain, shortness of breath, or leg pain, which can be a sign of atherosclerosis or peripheral artery disease. However, many people with high cholesterol may not experience any symptoms at all, which is why it is important to have regular cholesterol screenings and to make lifestyle changes to reduce the risk of developing heart disease. The diagnosis of hypercholesterolemia is typically made through a blood test that measures the levels of LDL and HDL cholesterol, as well as other lipid markers, such as triglycerides [4].

The American Heart Association recommends that adults over the age of 20 have their cholesterol levels checked every four to six years. If the results show that a person has high cholesterol, their doctor may recommend further testing and lifestyle changes to reduce the risk of heart disease. Treatment for hypercholesterolemia typically involves lifestyle changes and medications. The first line of treatment is usually dietary changes, such as reducing the intake of saturated and Trans fats and increasing the consumption of fruits, vegetables, whole grains, and lean protein sources. Exercise is also an important component of treatment, as it can help to increase HDL cholesterol levels and improve overall cardiovascular health. If lifestyle changes alone are not enough to lower cholesterol levels, medications may be prescribed. The most commonly used medications for hypercholesterolemia are statins, which work by inhibiting an enzyme in the liver that is responsible for producing cholesterol. Other medications that may be used include bile acid sequestrants, niacin, and fibrates. In addition to lifestyle changes and medications, there are several other treatments that may be used to lower cholesterol levels in certain cases. For example, people with a rare genetic condition called familial hypercholesterolemia may benefit from a procedure called LDL apheresis, which involves removing LDL cholesterol from the blood using a special machine. In some cases, surgery may be recommended to remove plaque from the arteries or to bypass blocked arteries [5].


Hypercholesterolemia is a common medical condition that affects millions of people worldwide. While cholesterol is necessary for the body to function properly, high levels of LDL cholesterol can lead to serious health problems, such as heart disease and stroke. Fortunately, hypercholesterolemia can be managed through a combination of lifestyle changes and medications. Dietary changes, regular exercise, and quitting smoking are all important steps that people can take to reduce their risk of developing high cholesterol. Additionally, medications such as statins can help to lower cholesterol levels and reduce the risk of heart disease. In some cases, other treatments, such as LDL apheresis or surgery, may be necessary. It is important for people to have their cholesterol levels checked regularly, especially if they have risk factors for hypercholesterolemia such as a family history of heart disease or being overweight. By working with a healthcare provider to manage high cholesterol, people can reduce their risk of developing serious health problems and enjoy a longer, healthier life.


  1. Koivisto UMMolecular Characterization of Minor Gene Rearrangements in Finnish Patients with Heterozygous Familial Hypercholesterolemia: Identification of Two Common Missense Mutations (Gly823-->Asp and Leu380-->His) and Eight Rare Mutations of the LDL Receptor Gene.Am J Hum Genet. 1995;57:789-97.
  2. Indexed at, Google Scholar

  3. Zerbino DR Ensembl 2018.Nucleic Acids Res. 2018;46:D754–D761.
  4. Google Scholar

  5. Yan D. Oxysterol Binding Protein Induces Upregulation of SREBP-1c and Enhances Hepatic Lipogenesis.. Arterioscler Thromb Vasc Biol. 2007;27:1108–1114.
  6. Google Scholar, Cross Ref

  7. Tang CS.Exome-Wide Association Analysis Reveals Novel Coding Sequence Variants Associated with Lipid Traits in Chinese..Nat Commun. 2015;6:10206.
  8. Indexed at, Google Scholar,href="" target="_blank">Cross Ref

  9. Auton A.A Global Reference for Human Genetic Variation.Nature. 2015;526:68–74.
  10. Indexed at, Google Scholar, Cross Ref

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