Review Article - Current Trends in Cardiology (2023) Volume 7, Issue 6
Exploring the impact of high blood pressure in heart functionTalal Almas*
Department of Health Sciences, University of L'Aquila, Aquila, Italy
- *Corresponding Author:
- Talal Almas
Department of Health Sciences
University of L'Aquila, Aquila, Italy
Received: 23-May-2023, Manuscript No. AACC-23- aacc-23-100744; Editor assigned: 26-May-2023, Pre QC No. AACC-23- aacc-23-100744(PQ); Reviewed: 09-Jun-2023, QC No. AACC-23- aacc-23-100744; Revised: 13-Jun-2023, Manuscript No. AACC-23- aacc-23-100744(R); Published: 21-Jun-2023, DOI:10.35841/aacc-7.6.173
Citation: Almas T. Exploring the impact of high blood pressure in heart function. J Cell Biol Metab. 2023;7(6):173
The kidneys and the heart share a remarkable physiological bond. The kidneys are responsible for filtering waste products and excess fluid from the bloodstream, regulating electrolyte balance, and maintaining blood pressure. In doing so, they help maintain cardiovascular homeostasis. Conversely, the heart is responsible for pumping oxygenated blood to all organs, including the kidneys, providing them with the necessary nutrients and oxygen. It is this close relationship that makes nephron cardiology an essential discipline in modern medicine. One of the primary areas of focus in nephron cardiology understands the bidirectional relationship between chronic kidney disease (CKD) and cardiovascular disease (CVD). CKD is a prevalent condition characterized by the gradual loss of kidney function over time. It is associated with several cardiovascular abnormalities, including hypertension, left ventricular hypertrophy, and accelerated atherosclerosis. Similarly, CVD, including coronary artery disease, heart failure, and arrhythmias, can adversely affect kidney function. The presence of one condition often predisposes an individual to develop the other, leading to a vicious cycle of decline in both organ systems [1-3].
Hypertension, or high blood pressure, is a common thread linking kidney and heart health. It is both a cause and a consequence of CKD and CVD. The kidneys play a crucial role in regulating blood pressure through the reninangiotensin- aldosterone system. Disruption of this system can lead to uncontrolled hypertension, which, in turn, damages the blood vessels and organs, including the heart and kidneys. By understanding the mechanisms underlying this relationship, nephron cardiologists can develop targeted therapies to manage hypertension and improve overall cardiovascular outcomes . Another area of interest in nephron cardiology is the management of fluid and electrolyte imbalances. The kidneys play a pivotal role in maintaining fluid balance by adjusting urine production. In conditions such as heart failure or advanced CKD, impaired cardiac function can lead to fluid overload. The resulting fluid retention can further compromise cardiac function and exacerbate kidney damage. By closely monitoring fluid status and employing interventions such as diuretic therapy or ultrafiltration, nephron cardiologists can help mitigate these imbalances, reducing the burden on both the heart and kidneys. Additionally, nephron cardiology encompasses the study of cardio renal syndrome (CRS), a term used to describe the complex interaction between cardiac and renal dysfunction. CRS can be classified into five subtypes, each with unique pathophysiological mechanisms. For instance, type 1 CRS involves acute worsening of cardiac function leading to acute kidney injury, whereas type 2 CRS refers to chronic abnormalities in cardiac function causing progressive kidney damage. Understanding these subtypes and their underlying mechanisms is crucial for early detection, appropriate risk stratification, and tailored therapeutic interventions .
The future of nephron cardiology holds great promise, with on-going research focused on several exciting areas. One such area is the development of novel biomarkers to identify individuals at high risk of developing nephron cardiovascular diseases. Early identification of these individuals would allow for targeted interventions and preventive strategies. Additionally, advancements in imaging techniques, such as cardiac magnetic resonance imaging (MRI) and renal Doppler ultrasound, provide valuable insights into the structural and functional changes
- Douglas P.S., Rzeszut A.K., Noel Bairey Merz C, et al. Career preferences and perceptions of cardiology among US internal medicine trainees factors influencing cardiology career choice. JAMA Cardiol. 2018;3:682–691.
- Bravata DM, Watts SA, Keefer AL, et al. Prevalence, predictors, and treatment of impostor syndrome: a systematic review. J Gen Intern Med. 2020;35:1252-75.
- Cader FA, Gupta A, Han JK, et al. How feeling like an imposter can impede your success. JACC Case Rep. 2021;3:347-49.
- Quine L. Workplace bullying, psychological distress, and job satisfaction in junior doctors. Camb Q Healthc Ethics. 2003;12:91–101.
- Dzau VJ, Johnson PA. Ending sexual harassment in academic medicine. N Engl J Med. 2018;379:1589–91.