Short Communication - Allied Journal of Medical Research (2023) Volume 7, Issue 4
Exploring the immunosenescence and inflammaging paradigms in geriatric medicineHurez Firth*
Department of Surgery, University of California, Irvine, United States
- *Corresponding Author:
- Hurez Firth
Department of Surgery
University of California
Irvine, United States
Received: 01-Jul-2023, Manuscript No. AAAJMR-23-106090; Editor assigned: 04-Jul-2022, PreQC No. AAAJMR-23-106090(PQ); Reviewed: 18-Jul-2023, QC No. AAAJMR-23-106090; Revised: 21-Jul-2023, Manuscript No. AAAJMR-23-106090(R); Published: 28-Jul-2023, DOI:10.35841/aaajmr-7.4.189
Citation: Firth H. Exploring the immunosenescence and inflammaging paradigms in geriatric medicine. Allied J Med Res. 2023;7(4):189
Aging is a complex process accompanied by changes in the immune system and chronic low-grade inflammation, which have significant implications for the health and well-being of older adults. Immunosenescence and inflammaging are two closely interconnected paradigms that contribute to agerelated alterations in immune function and the development of age-associated diseases. In this article, we delve into the fascinating field of geriatric medicine, exploring the concepts of immunosenescence and inflammaging, their underlying mechanisms, and their impact on health and disease in the elderly population. Immunosenescence refers to the gradual decline in immune function that occurs with age. The aging immune system undergoes various changes, including alterations in the production and function of immune cells, decreased response to infections and vaccinations, and impaired ability to mount effective immune responses. These changes leave older adults more susceptible to infections, autoimmune diseases, and malignancies. Key factors contributing to immunosenescence include thymic involution, reduced production of naïve T cells, telomere shortening, and dysregulation of immune signaling pathways .
Inflammaging is a state of chronic low-grade inflammation that occurs in older adults. It is characterized by increased levels of pro-inflammatory cytokines, such as Interleukin-6 (IL-6), Tumor Necrosis Factor-alpha (TNF-α), and C-Reactive Protein (CRP). Inflammaging arises from a combination of factors, including cellular senescence, accumulation of damaged cellular components, alterations in gut microbiota composition, and activation of the innate immune system. This chronic inflammatory state has been implicated in the pathogenesis of numerous age-related diseases, including cardiovascular disease, neurodegenerative disorders, and frailty. Immunosenescence and inflammaging are closely intertwined and interact with each other. Immunosenescence can contribute to inflammaging by promoting the accumulation of senescent cells that secrete pro-inflammatory mediators. On the other hand, inflammaging perpetuates immunosenescence by driving immune dysregulation and impairing the functionality of immune cells. The reciprocal relationship between these two processes creates a vicious cycle that can accelerate age-related disease progression and functional decline in older adults [2,3].
The consequences of immunosenescence and inflammaging on the health of older adults are profound. Impaired immune responses increase susceptibility to infections, decrease the effectiveness of vaccines, and impair wound healing. Chronic inflammation contributes to the development of agerelated chronic conditions, including cardiovascular disease, Alzheimer's disease, type 2 diabetes, and cancer. Furthermore, the combination of immunosenescence and inflammaging contributes to the development of frailty, a state of decreased physiological reserve and increased vulnerability to adverse health outcomes. Understanding the mechanisms underlying immunosenescence and inflammaging opens avenues for developing interventions to promote healthy aging and improve the quality of life for older adults. Strategies such as caloric restriction, regular physical activity, and modulation of the gut microbiota hold promise in attenuating these agerelated processes. Additionally, targeted immunotherapies, including senolytics and anti-inflammatory agents, are being investigated for their potential to mitigate immunosenescence and inflammaging and reduce the burden of age-related diseases .
Immunosenescence and inflammaging represent two key concepts in geriatric medicine that shed light on the agerelated changes in immune function and chronic low-grade inflammation observed in older adults. Understanding the interplay between these paradigms is crucial for developing effective interventions to promote healthy aging and mitigate the burden of age-related diseases. By targeting immunosenescence and inflammaging, we can strive to enhance the health span of older adults and improve their overall well-being in the face of an aging population .
- Milot E, Morissette-Thomas V, Li Q, et al. Trajectories of physiological dysregulation predicts mortality and health outcomes in a consistent manner across three populations. Mech Ageing Dev. 2014;141:56-63.
- Arbeev KG, Cohen AA, Arbeeva LS, et al. Optimal versus realized trajectories of physiological dysregulation in aging and their relation to sex-specific mortality risk. Public Health Front. 2016;4:3.
- Vel Szic KS, Declerck K, Vidakovic M, et al. From inflammaging to healthy aging by dietary lifestyle choices: Is epigenetics the key to personalized nutrition? Clin Epigen. 2015;7:1-8.
- Quach A, Levine ME, Tanaka T, et al. Epigenetic clock analysis of diet, exercise, education, and lifestyle factors. Aging. 2017;9(2):419.
- Campbell JM, Bellman SM, Stephenson MD, et al. Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis. Ageing Res. Rev. 2017;40:31-44.