Journal of Clinical Immunology Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +447723862070

Mini Review - Journal of Clinical Immunology Research (2022) Volume 5, Issue 1

Early-life innate immunity to respiratory infection.

Mohammed Rais*

Department of Health Science, Ibrahim Medical College, Dhaka, Bangladesh

*Corresponding Author:
Mohammed Rais
Department of Health Science
Ibrahim Medical College
Dhaka, Bangladesh
E-mail: [email protected]

Received: 07-Feb-2022, Manuscript No. aacir-22-56371; Editor assigned: 08-Feb-2022, PreQC No. aacir-22-56371 (PQ); Reviewed: 21-Feb-2022, QC No. aacir-22-56371; Revised: 25-Feb-2022, Manuscript No. aacir-22-56371 (R); Published: 28-Feb-2022, DOI: 10.35841/ aacir-5.1.103

Citation: Rais M. Early-life innate immunity to respiratory infection. J Clin Immunol. 2022;5(1):103

Visit for more related articles at Journal of Clinical Immunology Research


Early life is a time when infants are especially vulnerable to respiratory infections, and their symptoms are much more severe than in adults. Most aspects of the newborn immune system are thought to be defective; innate responses are weak, antigen-presenting cells have low immunostimulatory activity, and adaptive lymphocyte responses are limited, all of which contribute to poor immunological memory and suboptimal vaccine responses. The ability to distinguish between harmless and potentially dangerous antigens is critical for mucosal surfaces such as the lung, which are constantly exposed to airborne antigen and potential pathogenic invasion, to prevent inflammation that could lead to loss of gaseous exchange and damage to developing lung tissue.


Respiratory infections, Immune system, Neonates, Lungs.


One of the top causes of death in children under the age of five is respiratory illness. The illness is usually limited to the upper respiratory tract, but it can progress to a serious lower respiratory tract infection, such as RSV bronchiolitis, which is the primary cause of newborn hospitalization globally. Early life is a window of special risk to respiratory illness because maternal antibodies provide some protection against infection but diminish over the first months of life, and neonates and babies respond poorly to vaccination. Experiences during the critical newborn and infant window may have a longterm impact on respiratory health. Severe RSV infection in babies is linked to the development of wheeze and asthma in childhood, and even late-life respiratory diseases, such as chronic obstructive pulmonary disease, are linked to early life events [1].

At birth, the neonate emerges from the safe confines of the uterus to face a slew of antigenic assaults from pathogens, commensals, and harmless environmental antigens. In comparison to adult immunity, neonatal immunity is generally weakened [2].

Early Childhood Respiratory Immunity: Because obtaining samples from the lower airways of healthy infants is difficult, numerous researches have been conducted using murine and other animal models. Study of bronchoalveolar lavage fluid composition, immunohistochemistry, and, more recently, thorough phenotypic analysis of leukocyte subsets in paediatric tissues have all provided information on the cellular composition of the neonatal lung in humans [3].

Factors Affecting Lung Immunity Development and Maturation: Despite the lack of a mature adult-like immune system, neonates are capable of producing powerful immune responses that protect them from infection, and excessive inflammation can ensue. The neonate must find a balance between infection protection and potential lung injury, and may use anti-infection systems other than those found in adults [4].

As evidenced by the mitigation of allergic lung inflammation caused by airway exposure to LPS or endotoxin-rich dust samples, environmental microbial exposure may influence lung health by determining the set-point of immunological reactivity of the lung [5].


The mechanisms that control inflammatory responses in the lungs in response to microbial stimulation need to be better understood. In order to create newborn vaccinations and therapies for increased respiratory inflammation during infection, we need to learn more about how the growing immune system responds to viral challenge. The immune system in early life is capable of adult-level responses in some conditions, so possibly increasing responses in at-risk infants as part of an acute infectious disease treatment or as an adjuvant for vaccination would be a desirable protective strategy.


  1. Liu L, Oza S, Hogan D, et al. Global, regional, and national causes of child mortality in 2000–13, with projections to inform post-2015 priorities: an updated systematic analysis. The Lancet. 2015;385(9966):430-40.
  2. Indexed at, Google Scholar, Cross Ref

  3. Lambert L, Sagfors AM, Openshaw PJ, et al. Immunity to RSV in early-life. Front Immunol. 2014;5:466.
  4. Indexed at, Google Scholar, Cross Ref

  5. Mohr E, Siegrist CA. Vaccination in early life: standing up to the challenges. Curr Opin Immuno. 2016;41:1-8.
  6. Indexed at, Google Scholar, Cross Ref

  7. Biesbroek G, Tsivtsivadze E, Sanders EA, et al. Early respiratory microbiota composition determines bacterial succession patterns and respiratory health in children. Ame J respirator Crit Med. 2014;190(11):1283-92.
  8. Indexed at, Google Scholar, Cross Ref

  9. Martinez FD. Early-life origins of chronic obstructive pulmonary disease. New Eng J Med. 2016;375(9):871-78.
  10. Indexed at, Google Scholar, Cross Ref

Get the App

Vizag Tech Summit