Journal of Clinical Pathology and Laboratory Medicine

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +1 (202) 780-3397

Short Communication - Journal of Clinical Pathology and Laboratory Medicine (2023) Volume 5, Issue 5

Decoding health: The significance of a Complete Blood Count (CBC)

Qibin Qi*

Department of Pathology, Erasmus University College, Netherlands

*Corresponding Author:
Qibin Qi
Department of Pathology, Erasmus University College, Netherlands
Erasmus University College

Received:26-Sept-2023, Manuscript No. AACPLM-23-115527; Editor assigned: 28-Sept-2023, PreQC No. AACPLM-23-115527(PQ); Reviewed:11-Oct-2023, QC No. AACPLM-23-115527; Revised:16-Oct-2023, Manuscript No. AACPLM-23-115527(R); Published:23-Oct-2023, DOI:10.35841/ aacplm-5.5.169

Citation: Qi Q. Mean Corpuscular Volume (MCV): Deciphering blood cell size for health. J Clin Path Lab Med. 2023;5(5):169


A Complete Blood Count (CBC) is one of the most common blood tests performed in medicine, providing valuable insights into a person's overall health. This comprehensive analysis of blood components offers a window into various aspects of a patient's well-being, aiding in the diagnosis and management of numerous medical conditions. In this article, we delve into the world of CBC, exploring its components, importance, and clinical applications[1].

Red Blood Cells (RBCs): RBCs are responsible for carrying oxygen from the lungs to the body's tissues and returning carbon dioxide to the lungs for exhalation. The CBC measures parameters such as haemoglobin, haematocrit, and RBC count, which are crucial for assessing anemia and oxygen-carrying capacity. White Blood Cells (WBCs): WBCs are essential for the body's immune response, defending against infections and foreign invaders. The CBC provides a WBC count and differential count, which identifies the different types of WBCs, helping to diagnose infections and disorders like leukemia. Platelets: Platelets are small cell fragments that play a vital role in blood clotting. A CBC includes a platelet count, which is essential for evaluating bleeding disorders and monitoring clotting potential[2].

Haemoglobin (Hb) Concentration: Haemoglobin is the protein in RBCs that binds to oxygen. Low haemoglobin levels can indicate anemia, while high levels may suggest dehydration or certain medical conditions. Mean Corpuscular Volume (MCV): MCV measures the average size of RBCs. It helps classify anaemias as microcytic (small cells), normocytic (normal-sized cells), or macrocytic (large cells). Mean Corpuscular Haemoglobin (MCH) and MCH Concentration (MCHC): These parameters assess the average haemoglobin content and concentration within RBCs, providing additional information about anemia types. Anemia Diagnosis: A CBC is a primary tool for diagnosing anemia, which can result from various causes, including iron deficiency, vitamin deficiencies, chronic diseases, or blood loss[3].

Infection Detection: An elevated WBC count, particularly the neutrophil count, can indicate an infection. Monitoring changes in WBC counts helps assess the body's response to infections or inflammatory conditions. Bone Marrow Disorders: Abnormalities in blood cell counts and morphology may suggest underlying bone marrow disorders, such as leukemia, myelodysplastic syndromes (MDS), or aplastic anemia[4].

Monitoring Chronic Conditions: CBCs are used to track the progress of chronic diseases like HIV/AIDS, autoimmune disorders, and cancers. Changes in blood cell counts can indicate disease progression or response to treatment. Preoperative Assessment: Physicians often request CBCs before surgeries to assess a patient's overall health and risk of excessive bleeding during surgery[5].


A Complete Blood Count, often referred to as the "bread and butter" of laboratory medicine, is an indispensable tool for healthcare providers. It serves as a fundamental diagnostic and monitoring tool for a wide range of medical conditions, from anemias to infections and bone marrow disorders. Regular CBCs enable early detection, accurate diagnosis, and effective management of health issues, ultimately contributing to better patient care and improved overall well-being.


  1. Lloyd-Jones D, Adams R, Carnethon M, et al. Heart disease and stroke statistics—2009 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2009;119(3):e21-181.
  2. Indexed at, Google Scholar, Cross Ref

  3. Heidenreich PA, Trogdon JG, Khavjou OA, et al. Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association. Circulation. 2011;123(8):933-44.
  4. Indexed at, Google Scholar, Cross Ref

  5. Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation. 2002;105(9):1135-43.
  6. Indexed at, Google Scholar, Cross Ref

  7. Madjid M, Casscells SW, Willerson JT. Biomarkers of inflammation as surrogate markers in detection of vulnerable plaques and vulnerable patients. Cardiovasc. Med. 2007:641-51.
  8. Indexed at, Google Scholar, Cross Ref

  9. Madjid M, Awan I, Willerson JT, et al. Leukocyte count and coronary heart disease: implications for risk assessment. J Am Coll Cardiol. 2004;44(10):1945-56.
  10. Indexed at, Google Scholar, Cross Ref

Get the App