Hematology and Blood Disorders

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Mini Review - Hematology and Blood Disorders (2023) Volume 6, Issue 4

Blood clotting disorders: Understanding the silent threat

Max Sterling *

Department of Hematology, Harvard University, United States

*Corresponding Author:
Max Sterling
Department of Hematology, Harvard University, United States
E-mail: Max11@harvard.edu

Received: 28-Feb-2024, Manuscript No. AAHBD-24-136385; Editor assigned: 01-Mar-2024, PreQC No AAHBD-24-136385 (PQ) Reviewed:14-Mar-2024, QC No. AAHBD-24-136385Revised:20-Mar-2024, Manuscript No. AAHBD-24-136385 (R); Published:27-Mar-2024, DOI:10.35841/aahbd-6.4.156

Citation: Sterling M. Blood clotting disorders: Understanding the silent threat. Hematol Blood Disord. 2024;6(4):156

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Blood clotting, or coagulation, is a critical physiological process that prevents excessive bleeding when blood vessels are injured. This process involves a complex cascade of events where platelets and various clotting factors work together to form a stable clot. However, disruptions in this balance can lead to blood clotting disorders, which can be either hypercoagulable (excessive clotting) or hypocoagulable (insufficient clotting) [1].

These disorders have significant health implications, ranging from minor bruising to life-threatening events such as strokes, heart attacks, or severe bleeding episodes. This article explores the types, causes, symptoms, and treatments of blood clotting disorders [2].

Hemophilia: A genetic disorder where blood does not clot properly due to the absence or malfunction of certain clotting factors. Hemophilia A and B are the most common forms, resulting from deficiencies in factors VIII and IX, respectively [3].

Von Willebrand Disease (VWD): The most common inherited bleeding disorder, caused by a deficiency or dysfunction of von Willebrand factor, which helps platelets stick to the blood vessel wall and to each other [4].

Deep Vein Thrombosis (DVT): A condition where blood clots form in the deep veins, usually in the legs, which can dislodge and travel to the lungs, causing a pulmonary embolism (PE). Pulmonary Embolism (PE): A blockage in one of the pulmonary arteries in the lungs, typically caused by blood clots that travel from the legs [5].

Thrombophilia: A group of disorders where there is an increased tendency to form abnormal blood clots in blood vessels, potentially leading to DVT or PE. This can be due to genetic factors like Factor V Leiden mutation or acquired conditions like antiphospholipid syndrome [6].

Blood clotting disorders can be inherited or acquired. Genetic causes include mutations in specific genes that control clotting factor production or function. For instance, Hemophilia and Von Willebrand Disease are inherited disorders, while Factor V Leiden mutation and Prothrombin gene mutation increase clotting risk [7].

Acquired causes include prolonged immobility, surgery, trauma, cancer, and certain medications like oral contraceptives or hormone replacement therapy. Conditions such as obesity, smoking, and chronic diseases like diabetes and hypertension also elevate the risk of developing clotting disorders [8].

The symptoms of blood clotting disorders vary depending on the type and severity. Common symptoms include: For bleeding disorders: Excessive bleeding from cuts, frequent nosebleeds, easy bruising, heavy menstrual periods, and prolonged bleeding after surgery or dental work. For clotting disorders: Swelling, pain, and redness in the affected area (commonly the legs), shortness of breath, chest pain, and sudden cough with blood, which are indicative of DVT or PE [9].

The treatment for blood clotting disorders depends on the specific condition and its severity. Common treatments include: For bleeding disorders: Replacement therapy with clotting factors, desmopressin (DDAVP) for mild cases, and antifibrinolytic agents to prevent the breakdown of clots. For clotting disorders: Anticoagulants (blood thinners) like warfarin, heparin, and newer oral anticoagulants (NOACs) such as rivaroxaban and apixaban. In some cases, thrombolytic therapy is used to dissolve clots [10].


Blood clotting disorders represent a significant health concern with diverse manifestations and potential complications. Early diagnosis and appropriate management are crucial to mitigate risks and improve patient outcomes. Advances in genetic testing and targeted therapies hold promise for more personalized and effective treatments. Awareness and education about these disorders can help individuals recognize symptoms early and seek timely medical intervention.


  1. Soucie JM, Evatt B, Jackson D. Occurrence of hemophilia in the United States. American J hematol. 1998;59(4):288-94.
  2. Indexed at, Google Scholar, Cross Ref

  3. Brennan MD, Miner KM, Rizza RA. The Mayo Clinic. J Cli Endo & Met. 1998;83(10):3427-34.
  4. Indexed at, Google Scholar

  5. Scarvelis D, Wells PS. Diagnosis and treatment of deep-vein thrombosis. Cmaj. 2006 4;175(9):1087-92.
  6. Indexed at, Google Scholar

  7. Kumar DR, Krishna TA, Wahi A. Health monitoring framework for in time recognition of pulmonary embolism using internet of things. J Comp Theor Nanosci. 2018;15(5):1598-602.
  8. Indexed at, Google Scholar, Cross Ref

  9. Zheng J, Zhang D. SimBoolNet—a Cytoscape plugin for dynamic simulation of signaling networks. Bioinformatics. 2010;26(1):141-2.
  10. Indexed at, Google Scholar, Cross Ref

  11. Gönen T, Usgu S, Akbayram S, Yakut Y. Is YouTube a Reliable Source of Medical Information About Hemophilia?.
  12. Indexed at, Google Scholar, Cross Ref

  13. Stonebraker JS,. The world federation of hemophilia annual global survey 1999?2018. Haemophilia. 2020;26(4):591-600.
  14. Indexed at, Google Scholar, Cross Ref

  15. De Michele M,. Cerebrovascular complications of COVID-19 and COVID-19 vaccination. Circulation Research. 2022;130(8):1187-203.
  16. Indexed at, Google Scholar, Cross Ref

  17. Goose N. Current bibliography of urban history.
  18. Indexed at, Google Scholar, Cross Ref

  19. Patton LL. Bleeding and clotting disorders. Burket’s oral medicine: diagnosis and treatment. 10th ed. Hamilton (ON): BC Decker. 2003:454-77.
  20. Google Scholar

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