Editor Note - Hematology and Blood Disorders (2020) Volume 3, Issue 2
Advances in the field of hematologyAnkit Trivedi*
Aligarh Muslim University, Aligarh, India
- Corresponding Author:
- Ankit Trivedi
Aligarh Muslim University
E-mail: [email protected]
Hematology is the science or study of blood, blood-forming organs and blood diseases. In the medical field, hematology includes the treatment of blood disorders and malignancies, including types of hemophilia, leukemia, lymphoma and sicklecell anemia. Hematology is a branch of internal medicine that deals with the physiology, pathology, etiology, diagnosis, treatment, prognosis and prevention of blood-related disorders. Hematologists focus largely on lymphatic organs and bone marrow and may diagnose blood count irregularities or platelet irregularities. Hematologists treat organs that are fed by blood cells, including the lymph nodes, spleen, thymus and lymphoid tissue.
In volume 3 Issue 1, various aspects of hematology were discussed by the authors from different parts of the world. In the article Tom van Meerten studied that Future prospects for DLBCL treatment: Combination of WEE1 inhibitorswith CHOP and radiation therapy. Diffuse large B-cell lymphoma (DLBCL) is the mostaggressive and common form of non- Hodgkin lymphoma.DLBCL arises during B-cell development in the germinalcenter reaction as a result of high levels of genomicrearrangements to create high affinity B-cell receptors .
Renata Eleutério commented on Reduction of frequency of pain in clinical trial with association of arginineand hydroxyurea in sickle cell anemia's patients in Brazil. Arginine is a substrate for NO production, which is a cofactorof the enzyme guanylate cyclase (GC), responsible for thereaction that makes the conversion of guanosine triphosphate(GTP) into cyclic guanine monophosphate (cGMP), causing relaxation of smooth muscles and vascular and consequently vasodilation .
Adel Zeglam shared his views on Hypermanganesemia Revisited. Manganese (Mn) is a mineral that is considered an essential nutrient, involved in many chemicalprocesses in the body, including processing of cholesterol, carbohydrates, and protein. It might also beinvolved in bone formation. Fairly high doses of manganese in bacteria disrupt replication and repairof DNA and cause mutations in microorganisms and mammalian cells. Manganese in mammalian cellsinduces DNA damage and aberrations to the chromosome .
Francis Ajeneye reviwed about The critical push for traceability compliance: A District General Hospitalexperience. It is imperative to highlight the critical push for traceability ofblood and its products. The ability to trace the pathway of theblood from the recipient to the original donor and vice versa isan important public health safeguard. In addition, accuraterecord keeping is an essential part of professional practice Themandatory developments of the traceability process due toEuropean legislation, Blood Safety and Quality Regulation(BSQR), Clinical governance and patient safety has promptedthe necessity for this project .
Francis Ajeneye also cshared his views on on Eosinopenia as a Diagnostic Marker in Covid-19? Eosinopenia is defined as a decrease of circulating eosinophils<0.01 × 109/l. Eosinopenia is mediated by adrenalglucocorticosteroids and epinephrine in acute stress, whereas inacute inflammatory states, this is not reliant upon the endocrinemechanisms. The use of eosinopenia as a marker is encouraging observation in COVID-19 infection, besides require further investigation .
- Meerten T, de Jong M, Visser L. Future prospects for DLBCL treatment: Combination of WEE1 inhibitors with CHOP and radiationtherapy. Hematol Blood Disord 2020;3(1):21-22.
- Eleutério R. Reduction of frequency of pain in clinical trial with association of arginine and hydroxyurea in sickle cell anemia'spatients in Brazil Hematol Blood Disord 2020;3(1): 23-24.
- Zeglam A. Hypermanganesemia Revisited. Hematol Blood Disord 2020;3(1):25-30.
- Ajeneye F. The critical push for traceability compliance: A District General Hospital experience. Hematol Blood Disord 2020;3(1):28-32.
- Ajeneye F, Olofin O. Eosinopenia as a Diagnostic Marker in Covid-19? Hematol Blood Disord 2020;2(1):31-33.