40 Bloomsbury Way Lower Ground Floor, London, UK   (828) 214-3944   Home

Journal of RNA and Genomics

An open access publication – will publish high-quality, peer-reviewed articles addressing most aspects of short and long coding / non-coding RNA biology and application in biotechnology and therapy. The journal aims toward the worldwide dissemination of conceptual reviews and contemporary research findings related to RNA structure and function and genomics.

ISSN: 2591-7781

Archives

Establishment of a positive-readout reporter system for siRNAs

Authors : Wei-li Liu, Douglas P Owen, Kerry D Fisher, Leonard W Seymour and Mark Stevenson*
The use of small interfering RNA molecules for therapeutic applications requires development of improved delivery systems, a process that would be facilitated by a non-invasive positive-readout mouse model for studying siRNA pharmacodynamics. Positiv
Abstract | Full-Text | PDF

Selective RNAi-mediated inhibition of mutated c-kit

Authors : Irene Ruano and Marta Izquierdo*
The proto-oncogene c-kit plays an important role in the development and survival of mast cells. Gain-offunction mutations in c-kit are one of the most characteristic events in mast cell leukemia (MCL) but as yet there is no clinically approved treatm
Abstract | Full-Text | PDF

Potent subunit-specific effects on cell growth and drug sensitivity from optimised siRNA-mediated silencing of ribonucleotide reductase

Authors : Glen Reid*, Natacha Coppieters ?t Wallant, Rachna Patel, Ana Antonic, Faamatala Saxon-Aliifaalogo, Helen Cao, Gill Webster and James D Watson
Ribonucleotide reductase (RR) has an essential role in DNA synthesis and repair and is a therapeutic target in a number of different cancers. Previous studies have shown that RNAi-mediated knockdown of either the RRM1 or RRM2 subunit sensitizes cells
Abstract | Full-Text | PDF

First siRNA library screening in hard-to-transfect HUVEC cells

Authors : Markus Zumbansen, Ludger M Altrogge, Nicole UE Spottke, Sonja Spicker, Sheila M Offizier, Sandra BS Domzalski, Allison L St Amand, Andrea Toell, Devin Leake and Herbert A Mueller-Hartmann*
Meaningful RNAi-based data for target gene identification are strongly dependent on the use of a biologically relevant cell type and efficient delivery of highly functional siRNA reagents into the selected cell type. Here we report the use of the Ama
Abstract | Full-Text | PDF
Sidebar