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Journal of RNA and Genomics

An open access publication – will publish high-quality, peer-reviewed articles addressing most aspects of short and long coding / non-coding RNA biology and application in biotechnology and therapy. The journal aims toward the worldwide dissemination of conceptual reviews and contemporary research findings related to RNA structure and function and genomics.

ISSN: 1747-0854

Archives

The cleavage of target mRNA by ribozymes is being exploited as a means of gene silencing in nucleic-acidbased therapies. We previously established an HIV-1-dependent ribozyme-expression vector system, based on Cre-loxP technology with an LTR-gag-p17
Abstract | Full-Text | PDF

Delivery of RNAi reagents in murine models of obesity and diabetes

Authors : Denise M Wilcox*, Ruojing Yang, Sherry J Morgan, Phong T Nguyen, Martin J Voorbach, Paul M Jung, Deanna L Haasch, Emily Lin, Eugene N Bush, Terry J Opgenorth, Peer B Jacobson, Christine A Collins, Cristina M Rondinone, Terry Surowy and Katherine T Landschulz
RNA interference (RNAi) is an exciting new tool to effect acute in vivo knockdown of genes for pharmacological target validation. Testing the application of this technology to metabolic disease targets, three RNAi delivery methods were compared in tw
Abstract | Full-Text | PDF

RNAi and cancer: Implications and applications

Authors : Maen Abdelrahim*, Stephen Safe, Cheryl Baker and Ala Abudayyeh
RNA interference (RNAi) is an endogenous process that regulates expression of genes and corresponding proteins to maintain homeostasis in diverse organisms. Non-coding RNAs (ncRNAs) including both long and short ncRNAs are widely expressed and levels
Abstract | Full-Text | PDF

Manipulating and enhancing the RNAi response

Authors : Peter I Joyce, Joseph M Gallagher and Patricia E Kuwabara*
The phenomenon that is known as RNA mediated interference (RNAi) was first observed in the nematode C. elegans. The application of RNAi has now been widely disseminated and the mechanisms underlying the pathway have been uncovered using both genetics
Abstract | Full-Text | PDF
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