Asian Journal of Biomedical and Pharmaceutical Sciences

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Wound Healing Activity of Tribulus Terrestris Linn. Fruits in Swiss Albino Rats

The main objective of this study was to evaluate the wound healing activity of Tribulus Terrestris Linn. (TT) fruits in swiss albino rats. The fruit body of Tribulus Terrestris rich in tannins and phenolic content. Dried fruits of Tribulus Terrestris powder were used for ointment preparation. Healthy adult swiss albino rats (18-22)g were subjected to acute toxicity studies as per OECD guidelines 423. The selected swiss albino rats were used for wound healing model experiments. Excision wounds were made by cutting a skin from the dorsal abdominal region. The prepared onitment were applied to the area where the excision wounds were made and the wound healing parameters like wound contraction rate were assessed and monitored every day. Rapid regeneration of tissues at the wound site indicates that the Tribulus Terrestris fruit showed the higher healing process by increasing the wound contraction level and decrease in epithelization period were also observed. The histopathological examination showed much advance phase of healing process, it was concluded that the ointment preparation of Tribulus Terrestris fruit showing higher wound healing activity compared to control in swiss albino rats.

Author(s): Amutha K, Anbu J, Selvakumari U