Combination of citicoline and piracetam is available in market as fixed dose combination in film coated tablet with dose of citicoline 500 mg and piracetam 800 mg. It has been approved by DCGI in the year 2010. This combination is chemically and pharmalogically safe. The combination is generally prescribed for memory enhancement, neurological and cognitive disorder, Parkinsonism and Alzheimer disorder. These drugs are nutrients and acts as cognition enhancing supplements, and are recommended as part of treatment regimens at some aging clinics. Citicoline has been shown to improve memory and other cognitive functions in patients with chronic cerebrovascular disease or dementia and in old people suffering from memory deficit. Piracetam is a drug which enhances cognition and memory, slows brain aging, increases oxygen and blood flow to the brain, improves Alzheimer's and aids in stroke recovery and related conditions. Piracetam and citicoline stimulate thought without peripheral nervous system stimulation. Citicoline alone gives a lift and then a depression but not when taken along with piracetam. Whereas piracetam induced headache is reduced when taken along with citicoline. This review highlights need for combination of citicoline and piracetam their pharmacological and therapeutic issues and application.