Asian Journal of Biomedical and Pharmaceutical Sciences

Journal Banner

The Effect of the Antioxidant Drug ?U-74389G? On Oviductal Congestion during Ischemia Reperfusion Injury in Rats

The effect of the antioxidant drug “U-74389G” was examined, on rat model and particularly in an oviductal ischemia reperfusion (IR) protocol. The probable effects of that molecule were studied pathologically using oviductal congestion (OC) lesions. 40 rats of mean weight 231.875 g were used in the study. OC lesions were evaluated at 60 min of reperfusion (groups A and C) and at 120 min of reperfusion (groups B and D) in rats. U-74389G was administered only in groups C and D. U-74389G administration non-significantly altered the OC scores by 0 without lesions [-0.3582422 - 0.3582422] (p=0.9608). Reperfusion time non-significantly increased the OC scores by 0.2 without lesions [-0.1521699 - 0.5521699] (p= 0.2317). However, U-74389G administration and reperfusion time together significantly increased the OC scores by 0.0909091 without lesions [-0.1230462 - 0.3048644] (p=0.3951). U-74389G administration whether it interacted or not with reperfusion time failed to restore the OC lesions within short-term time context of 2 hours.

Author(s): Tsompos C, Panoulis C, Toutouzas K, Zografos G, Papalois A