Asian Journal of Biomedical and Pharmaceutical Sciences

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Supercritical Fluid Extraction-A Green Paradigm in the Area of Separation Science

Supercritical fluids are increasingly replacing the organic solvents that are used in industrial purification and recrystallization operations because of regulatory and environmental pressures on hydrocarbon and ozone-depleting emissions. With increasing scrutiny of solvent residues in pharmaceuticals, medical products, and neutraceuticals, and with stricter regulations the use of supercritical fluids is rapidly proliferating in all industrial sectors. One such major application is the use of supercritical fluids for extraction which is an environment-friendly process. Extracts obtained using this technology is superior in quality with higher yield and no residual solvent. In all the extraction processes generally carbon dioxide is used as solvent, which is regarded as safe for extraction of natural products. The extraction processes are being commercialized in the polymers, pharmaceuticals, specialty lubricants and fine chemicals industries and are advantageously applied to increasing product performance to levels that cannot be achieved by traditional technologies. Such applications for supercritical fluids offer the potential for both technical and economic success.

Author(s): Anita Ayre, Komal Ghude, Priya Mane, Mayuri Nemade , Sonali Gosavi, Akshaya Pathare, Anuja Lad