Asian Journal of Biomedical and Pharmaceutical Sciences

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Study of Solvent and Temperature Effects on Volumetric, Viscometric and Conductometric Studies of Amlodipine Besylate

Volumetric, viscometric and conductometric studies of 0.8 x 10-3 to 8 x 10-3 mol/Kg solutions of amlodipine besylate in distilled water and methanol were done at temperature range of 293.15, 298.15, 303.15, 308.15, 313.15, 318.5 and 323.15 K. from the determined values of density apparent molar volume ( ) and viscosity (η) were evaluated. Density data was analyzed and discussed using Masson empirical relationship and that of viscosity to Jones-Dole equation to evaluate partial molar volume ( ), intrinsic co-efficient SV, viscosity A and B parameters. All parameters were discussed as a function of concentration and temperature. For all set of dilutions conductometric studies in both solvents of study were employed. Obtained data was analyzed to judge the ion-ion and ion-solvent interactions. Structure making and breaking aspects of amlodipine besylate in polar solvents were discussed. These all parameters were studied to disclose the mechanism of action of drug and its transportation across biological membranes. Keywords: Apparent molar volume; partial molar

Author(s): Munir AQ, Ali M