The Osteoarthritis (OA) is age related degenerative joint disease. Osteoarthritis is the most common disease of women after menopause. There are many factors to develop the disease. Hormones play important role to in this context. The objective of the present study is to compare the neuromuscular performance characteristics in the two group of subjects. A total 100 menopausal women’s with OA and 50 normal menopausal women’s were included in the study. The Ground reaction forces, Peak instantaneous power, Concentric net impulse, Knee extension force, Knee flexion force are collected in the study. The postmenopausal women’s having mild osteoarthritis showed the lower neuromuscular performance characteristics. Data between the two groups represent that the regular exercise is needed to prevent such condition.