Serum gamma glutamyl transferes. It is a reliable diagnostic marker of alcohol ingestion which is one of the most sensitive and most commonly employed biochemical marker of alcohol consumption. This study was carried out with 30 alcoholic and 30 normal non-alcoholic male as control subject. A significant correlation in the level of serum GGT is observed in alcoholics (68.33±±16.7) when compared with the normal subjects (19.31± 10.20) with p value (p<0.05). Measurement of GGT enzyme activity in serum appears to be a sensitive index with low specificity in the diagnosis of alcoholics with hepatitis when correlated clinically.