Asian Journal of Biomedical and Pharmaceutical Sciences

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Stability Study of Griseofulvin in Non Aqueous Microemulsion System

New non aqueous based microemulsion allows the delivery of storage sensitive personal care actives in conventional cream, lotion and gel. Griseofulvin is an antifungal antibiotic drug micro emulsion system as the basic formulation for investigation. The quantity of griseofulvin and the accumulation of anhydrous micro emulsions at various temperatures were analyzed with poor aqueous solubility. It is thought to inhibit fungal cell mitosis and nuclear acid synthesis. Pharmaceutical and cosmetic micro emulsions are normally oil-in-water (o/w) or water-in-oil (w/o) systems; however, micro emulsions can be formulated with no aqueous phase to produce an anhydrous micro emulsion system. An anhydrous micro emulsion system could offer a stable vehicle for compounds that are sensitive to hydrolysis or oxidation. Therefore, to enhance the stability of griseofulvin in formulations, we chose the non aqueous, anhydrous through an established ultra violet (uv) method. The results indicated that Stability of griseofulvin in non aqueous microemulsion carried out at at temperature 5°C, 25°C and 40°C. Cream was stable at 5°C and 25°C. Stability studies were carried out at agitation, centrifugation, freeze thaw cycle, in that evaluated various parameter i.e phase separation, globule size, viscosity, drug content.

Author(s): Jadhav CM, Kate VK, Payghan SA