Asian Journal of Biomedical and Pharmaceutical Sciences

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Solubility Enhancement of Telmisartan Using Mixed Hydrotropy Approach

The present study was aimed at enhancement of telmisartan solubility using mixed hydrotropy approach. Telmisartan is a angiotensin II receptor antagonist used as antihypertensive. The effect of various hydrotropes at fixed concentration (40%) was probed to screen suitable hydrotropes for further studies except piperazine anhydrous and sodium benzoate (20%). Moreover effect of selected hydrotropes at different concentrations (10%, 20%, 30%, 40%) and blends of hydrotropes (10%) on solubility of telmisartan was investigated. The results indicated remarkable enhancement in solubility with sodium benzoate and sodium salicylate respectively. The mixed hydrotropic solution BD (Urea, PEG 4000 PEG 6000) showed 15737 folds improved solubility though other blends also gave the comparable results. The interference of various solubilizers in spectrophotometric estimation of Telmisartan was examined and no interference was observed. The contribution of pH in Telmisartan solubility enhancement was negligible

Author(s): Phulzalke S.B, Kate B.A, Bagade M. Y.