A simple and sensitive UV Spectrophotometric method have been developed for the estimation of ormeloxifene hydrochloride in pure and pharmaceutical dosage forms, using methanol as solvent. This method is based on the UV absorption maximum at 281nm. The absorbance of the UV is measured against the corresponding reagent blank. The method was validated statistically and by recovery studies .The LOD (limit of detection) and LOQ (limit of quantification) for Ormeloxifene hydrochloride were found to be 0.4μg/ml and 1.2μg/ml, respectively. The correlation coefficient value was found to be 0.9999. The % assay was found to be 99.98%. This method have been statistically evaluated and found to be precise and accurate.