Objectives: Abnormal liver enzyme levels might be observed with typhoid fever indicating liver involvement. Although, jaundice is unusual and infrequently reported in children, it declares the occurrence of complication. The aim was to evaluate the efficacy of some anti-typhoid drugs in typhoid hepatitis in children through measuring liver transaminase enzymes levels. Patients and Methods: 123 typhoid pediatric patients with high liver transaminase enzymes levels were participated and randomly allocated into 3 groups receiving cefixime (20 mg/kg/day), chloramphenicol (50 mg/kg/day) and amoxicillin (100mg/kg/ day) for two weeks. The obtained data were analyzed using SPSS (version 12) and were expressed as mean ± SEM and the difference among means has been analyzed by student's t test. Results: 64.8% had higher levels of Alanine transaminase than Aspartate transaminase while only 12.5% showed the opposite. At the end of the treatment; 68.3% had normally-returned alanine transaminase level before aspartate transaminase level, while 31.7% had the opposite. Conclusion: Estimation of alanine transaminase level in typhoid hepatitis during and after treatment gives a clue for the efficacy of the used drugs.