Asian Journal of Biomedical and Pharmaceutical Sciences

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Screening of Methanolic Extract of Pongamia Pinnata Leaves for its Antiarthritic and Analgesic Activity

The aim of present work was to screen traditional claim of methanolic extract of Pongamia pinnata (PP) leaves for its antiarthritic and analgesic activity. The antiarthritic activity of different doses of PP extract (100,200 and 400 mg/kg) in rats were evaluated on 7th and 14th day of treatment. The paw volume displacement, radiographic analysis, histopathological investigation and secondary changes were measured, as a mark of activity. The analgesic activity of the different doses of the extract in rats was evaluated using hot plate model. The PP extract at the dose of 200 and 400mg/kg showed significant reduction in paw volume on 7th and 14th day of treatment and also significant effect in radiographic and histopathological analysis but, none of the doses of PP extract showed any significant effect as analgesic.

Author(s): Arote SR, Yeole PG