Neem has a history of use primary against household and storage pests and to a limited extent against crop pests in the Indian subcontinent. Neem pesticides are more reliable, economic, eco-friendly and proved to be environmentally safe and effective against number of insects and pests. Enormous investigations have been carried out the extract obtained from the different parts of the neem plants against different insect and pest on crop plant. In the last decades plant extracts with insecticidal properties have evoked a substantial scientific and practical interest as a natural means of insect and mite pest control in sustainable agriculture. Keeping this in view, the present study is aimed to find out the scanning electron microscopic changes in the fat body of the adult male Odontopus varicornis treated with the sub-lethal concentration (LD 50, 3.25%) of Nimbecidine for 96h. The present results revealed that characteristics SEM changes in the fat body of treated insect than control insect such as shrunken ruffled membrane with small pinocytotic pits. The disorganized cytoplasmic inorgination indicates the occurrence of less amount of storage substance may probably be utilized for the insects to avoid the stress during the Nimbecidine intoxication.