Thyroid disorders are common all around the world, predominantly in females. A similar situation exists in Pakistan. Present case control study was designed to analyze the relevance of various symptoms with the disease and how their occurrence varies in normal population. For this purpose data of 400 patients suffering from any of thyroid related disease was collected. The controls were age and sex matched to make sure that results are not misleading in case if they are age and sex dependent. In the present study female to male ratio in both types of thyroidism i.e. hypothyroidism and hyperthyroidism was 3:1. Various symptoms like menstrual cycle, still birth, lactation problems in patients showed significant differences from controls. While some others being similar in both like dry hair showed that these symptoms are not disease specific. In addition the incidence being high in specific areas showed the relevance of the disease with environment.